A comprehensive review of Huangqin (<i>Scutellaria baicalensis</i> Georgi) tea: chemical composition, functional properties and safety aspects

Yining Quan; Zhenpeng Li; Xiangying Meng; Panpan Li; Yanying Wang; Chunnian He; Jie Shen; Yining Quan; Zhenpeng Li; Xiangying Meng; Panpan Li; Yanying Wang; Chunnian He; Jie Shen

doi:10.48130/BPR-2023-0031

Figures (2) Tables (1)

Figure 1.
The aerial parts of S. baicalensis Georgi, dried and brewed Huangqin tea.
Figure 2.
Chemical structure of flavonoids in HQT.

Number	Name	Formula	Species	Ref.
1	2',5-Dihydroxy-3',6,7,8-tetramethoxyflavone	C₁₉H₁₈O₈	S. baicalensis	[17]
2	2',6-Dihydroxyflavone	C₁₅H₁₀O₄	S. baicalensis	[16]
3	3',4',5,5',7-Pentamethoxyflavone	C₂₀H₂₀O₇	S. baicalensis	[16]
4	4',5-Dihydroxy-3',5',6,7-tetramethoxyflavone	C₁₉H₁₈O₈	S. baicalensis	[22,27]
5	4',5-Dihydroxy-7-methoxyflavanone	C₁₆H₁₄O₅	S. baicalensis	[16]
6	5,4′-Dihydroxy-6,7,8,3′-tetramethoxyflavone	C₁₉H₁₈O₈	S. baicalensis	[17]
7	5,2′-Dihydroxy-6,7,8-trimethoxyflavone	C₁₈H₁₆O₇	S. baicalensis	[17]
8	5,2′-Dihydroxy-6,7,8,3′-tetramethoxyflavone	C₁₉H₁₈O₈	S. baicalensis	[17]
9	5,2′-Dihydroxy-7,8-dimethoxyflavone	C₁₇H₁₄O₆	S. baicalensis	[17]
10	5,2′-Dihydroxy-7,8,6′-trimethoxyflavone	C₁₈H₁₆O₇	S. baicalensis	[17]
11	5,6,7,3',4'-Pentahydroxyflavone-7-O-glucuronide	C₂₁H₂₀O₁₃	S. baicalensis	[13]
12	5,6,7,4'-Tetrahydroxydihydroflavone	C₁₅H₁₂O₆	S. baicalensis	[17]
13	5,6,7-Trihydroxy-4'-methoxyflavone	C₁₆H₁₂O₆	S. baicalensis	[15]
14	5,7-Dihydroxy-6-methoxyflavanon	C₁₆H₁₄O₅	S. baicalensis	[17]
15	5,7,4′-Trihydroxy-6-methoxyflavanone	C₁₆H₁₄O₆	S. baicalensis	[22]
16	5,7,4'-Trihydroxyflavanone	C₁₅H₁₂O₆	S. baicalensis	[13]
17	(2S)-5,7,8,4'-Tetrahydroxyflavanone 7-O-β-D-glucuronopyranoside	C₂₁H₂₀O₁₂	S. baicalensis	[21]
18	(2S)-5,6,7,4'-Tetrahydroxyflavanone 7-O-β-D-glucuronopyranoside	C₂₁H₂₀O₁₂	S. baicalensis	[21]
19	6-Hydroxyluteolin-7-O-glucuronide	C₂₁H₁₈O₁₃	S. baicalensis	[13]
20	7-Methoxychrysin	C₁₆H₁₄O₄	S. baicalensis	[16]
21	Apigenin	C₁₅H₁₀O₅	S. baicalensis, S. amoena, S. scordifolia, S. viscidula	[17,21−25]
22	Apigenin-4'-glucopyranside	C₂₁H₂₀O₁₀	S. baicalensis	[17]
23	Apigenin-6-C-glucoside-8-C-arabinoside	C₂₆H₂₈O₁₄	S. baicalensis	[13]
24	Apigenin-7-O-β-D-glucopyranside	C₂₁H₂₀O₁₀	S. baicalensis	[17]
25	Apigenin-7-O-β-D-glucuronide	C₂₁H₁₈O₁₁	S. baicalensis, S. amoena, S. scordifolia	[13,23,24]
26	Apigenin-7-O-methylglucuronide	C₂₂H₂₀O₁₁	S. baicalensis	[28]
27	Baicalein	C₁₅H₁₀O₅	S. baicalensis, S. amoena, S. scordifolia, S. viscidula	[22−25]
28	Baicalein-7-O-D-glucopyranside	C₂₁H₂₀O₁₀	S. baicalensis	[22]
29	Baicalin	C₂₁H₁₈O₁₁	S. baicalensis, S. amoena, S. scordifolia, S. viscidula	[16,23−25]
30	Carthamidin	C₁₅H₁₂O₆	S. baicalensis	[13,20]
31	Carthamidin-7-O-β-D-glucuronide	C₂₁H₂₀O₁₂	S. baicalensis	[22]
32	Chrysin	C₁₅H₁₀O₄	S. baicalensis, S. amoena, S. scordifolia	[13,21−24]
33	Chrysin-7-O-β-D-glucuronide	C₂₁H₂₀O₉	S. baicalensis, S. amoena	[23,29]
34	Dihydrobaicalin	C₂₁H₂₀O₁₁	S. baicalensis	[22,28]
35	Dihydrooroxylin A	C₂₁H₂₀O₁₁	S. baicalensis	[13]
36	Genkwanin	C₁₆H₁₂O₅	S. baicalensis	[16]
37	Isocarthamidin	C₁₅H₁₀O₆	S. baicalensis	[20,28]
38	Isocarthamidin-7-O-β-D-glucuronide	C₂₁H₂₀O₁₂	S. baicalensis	[28]
39	Isoschaftside	C₂₆H₂₈O₁₄	S. baicalensis	[13,16]
40	Isoscutellarein	C₁₅H₁₀O₆	S. baicalensis	[21,30]
41	Isoscutellarein 8-O-β-D-glucuronide	C₂₁H₁₈O₁₂	S. baicalensis	[21]
42	Kaempferol 3-O-β-D-glucopyranoside	C₂₁H₂₀O₁₁	S. baicalensis	[13,28]
43	Luteolin	C₁₅H₁₀O₆	S. baicalensis	[22,30]
44	Norwogonin-7-O-glucuronide	C₂₁H₁₈O₁₂	S. baicalensis, S. amoena	[13,17,23]
45	Oroxylin A	C₁₆H₁₂O₅	S. baicalensis, S. amoena	[17,23]
46	Oroxylin A-7-O-D-glucopyranside	C₂₂H₂₂O₁₀	S. baicalensis	[22,28]
47	Oroxylin A-7-O-β-D-glucuronide	C₂₂H₂₀O₁₁	S. baicalensis, S. amoena	[13,23]
48	Pinocembrin	C₁₆H₁₂O₅	S. baicalensis	[13]
49	Pinocembrin-7-O-glucuronide	C₂₁H₂₀O₁₁	S. baicalensis	[13,16,22]
50	Salvigenin	C₁₈H₁₆O₆	S. baicalensis	[21]
51	Scutellarein	C₁₅H₁₀O₆	S. baicalensis	[28]
52	Scutellarin	C₂₁H₁₈O₁₂	S. baicalensis, S. amoena, S. scordifolia, S. viscidula	[23−25,29]
53	Wogonin	C₁₆H₁₂O₅	S. baicalensis, S. amoena, S. scordifolia, S. viscidula	[21−25]
54	Wogonoside	C₂₂H₂₀O₁₁	S. baicalensis, S. viscidula	[13,25]

Table 1.

Flavonoids of HQT.