Figures (3)  Tables (1)

    • Figure 1. 

      Combination of natural variations and spatial metabolomics to reveal key metabolite markers associated with important pharmaceutical properties[18].

    • Figure 2. 

      Phylogenetic tree constructed using the maximum likelihood (ML) and Bayesian inference methods based on the whole chloroplast genomes from 37 different species. The numbers above the branches represent the ML bootstrap values/BI posterior probabilities[28].

    • Figure 3. 

      Biological pathway for sesquiterpenoid synthesis in A. lancea. AACT: Acetyl-CoA-acetyltransferase; HMGS: Hydroxy methyl glutaryl-CoA synthase; HMGR: 3-hydroxy-3-methylglutaryl-coenzyme A reductase; MVK: Mevalonate kinase; PMK: Phosphomevalonate kinase; DXS: 1-deoxy-D-xylulose-5-phosphate synthase; DXR: 1-deoxy-Dxylulose-5-phosphate reductoisomerase; MCT: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; MDS: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; HDS: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; IDI: Isopentenyl-diphosphate delta-isomerase; GPPS: Geranyl diphosphate synthase; FPPS: Farnesyl diphosphate synthase; GGPPS: Geranylgeranyl pyrophosphate synthase; TPS: Terpenoid synthase.

    • Crude drugSpeciesGeographic
      distribution      		Volatile oil
      content (%)      		Atractylodin
      (%)      		β-eudesmol
      (%)      		Atractylone
      (%)      		Atractylenolide
      I (%)      		Atractylenolide
      II (%)      		Atractylenolide
      III (%)
      Atractylodis
      Rhizoma      		A. lanceaMainly in Jiangsu, Zhejiang, Hubei, Sichuan and other places south of the Qinling Mountains.5-90.314.40.390.0160.0130.007
      A. chinensisMainly in northeast, north and northwest areas north of the Qinling Mountains.3-50.340.250.350.0340.0210.016
      Atractylodis
      Macrocephalae
      Rhizoma      		A. macrocephalaIt is distributed in a small amount in Jiangxi, Zhejiang, Anhui and other regions.1-30.003/5.890.0250.0180.038
      A. japonicaNortheast China and Inner Mongolia, Hebei and other regions.1-30.140.0251.290.0330.0300.049
      A. coreanaA few areas in Qian Shan, Jilin and Inner Mongolia.2-30.28/0.08/0.020/

      Table 1. 

      Distribution, main active ingredients, and content of genus Atractylodes in China.