Common and Rare Histological Variants of Hepatoblastoma in Children: A Pathological Diagnosis and Review of the Literature

Sushma Bharti; Jyotsna Naresh Bharti; Arvind Sinha; Taruna Yadav; Sushma Bharti; Jyotsna Naresh Bharti; Arvind Sinha; Taruna Yadav

doi:10.1159/000512236

Figure 1.

CASE 1: Triple-phase contrast-enhanced CT axial (a–c) and coronal (d) images: in arterial phase, mass in right lobe shows peripheral arterial enhancement (a), portal venous (b), hepatic venous phases – progressive enhancement is seen in the periphery of the tumor with cystic nonenhancing areas in the center of the tumor (c, d). The rest of the liver shows normal enhancement.

Figure 2.

CASE 1: Mixed HB with the teratoid feature. a Gross: well-defined tumor nodule, abutting the capsular surface (H and E, ×200). b Microphotograph shows an epithelial component of HB. c Microphotograph shows Glial component and melanin pigment (H and E, ×200) (right upper inset showing GFAP immunopositivity). d Microphotograph shows osteoid and cartilage formation H and E, ×200). HB, hepatoblastoma.

Figure 3.

CASE 2: Mixed hepatoblastoma. a Gross: a tumor shows a variegated cut surface. b Microphotograph shows an epithelial component admixed with the mesenchymal component (H and E, ×200).

Figure 4.

CASE 3: Small-cell undifferentiated HB. a Microphotograph shows sheets and perivascular arrangement of dyscohesive small blue cells with scant cytoplasm (H and E, ×200). Tumor cells are immunoreactive for cytokeratin (b), vimentin (c), and focally for alpha-fetoprotein (d). HB, hepatoblastoma.