Figures (6)  Tables (1)

    • Figure 1. 

      Co-citation analysis of cited references.

    • Figure 2. 

      Bibliographic coupling analysis. (a) Network visualization. (b) Overlay visualization.

    • Figure 3. 

      Research hotspots and future trends. (a) Word frequency, (b) thematic analysis, and (c) TreeMap diagram.

    • Figure 4. 

      Panoramic overview of the common keywords and co-cited references.

    • Figure 5. 

      Timeline analysis and citation burst analysis.

    • Figure 6. 

      Co-words analysis. (a) Network visualization, (b) overlay visualization.

    • Authors (reference) Types of epigenetic modifications Location of epigenetic modifications Epigenetic regulatory mechanisms
      Fernandez-Cadenas I; Caty C; Natalia C;
      Jerzy K; Joan M;
      Elena M[14]      		 Site specific DNA methylation CpG sites within the TRAF gene Reduced DNA methylation of TRAF3, which activates immune responses, was closely linked to vascular recurrence and increased platelet aggregation in IS patients.
      Fernandez-Cadenas I; Jiménez-Conde J; Jaume R; Elisa CG; Natalia C; Eva GS[15] Site specific DNA methylation CpG sites within the THBS2, ZFP57, ALOX12, ABI3, ALLC genes Reduced DNA methylation at a CpG site in the THBS2 gene was linked to adverse stroke outcomes at three months. Furthermore, four differentially methylated regions (DMRs) were also associated with stroke outcome at the ZFP57, ALOX12, ABI3, and ALLC genes, which have all been implicated in atherogenesis and cognitive impairment.
      Fernandez-Cadenas I; Jiménez-Conde J; Jaume R; Caty C;
      Elisa CG; Eva GS;
      Joan M[16]      		 Global DNA methylation Genome-wide No global methylation differences were observed among IS subtypes large-artery atherosclerosis, small-artery disease, or cardio-aortic embolism.
      Fernandez-Cadenas I; Caty C;Natalia C;
      Jerzy K; Joan M;
      Elena M[37]      		 Site specific DNA methylation CpG sites within the PPM1A gene PPM1A methylation, influencing TGF-β1 signaling and the transcription of plasminogen activator inhibitor-1, was linked to vascular recurrence in aspirin-treated patients.
      Fernandez-Cadenas I; Jiménez-Conde J; Jaume R; Jerzy K;
      Joan M; Elena M[49]      		 Global DNA methylation CpG sites within the ZFHX3 and MAP3K1 genes Methylation of ZFHX3 and MAP3K1 regulates stroke subtype risk by altering gene expression. Hypomethylation of ZFHX3, involved in myogenic and neuronal differentiation, increases cardioembolic stroke risk, while MAP3K1 shows methylation changes linked to stroke. Mendelian randomization identifies these modifications as key drivers of cardioembolic, atherothrombotic, and lacunar stroke risk.
      Jiménez-Conde J;
      Elisa CG[41]      		 Global DNA methylation Genome-wide IS patients were found to be biologically older than their chronological age, especially in younger individuals, and exhibit significant increases in the Hannum DNA methylation clock.
      Jiménez-Conde J; Jaume R; Elisa CG;
      Eva GS[42]      		 Global DNA methylation Genome-wide The epigenetic clock, determined by DNA methylation, significantly accounts for the burden of white matter hyperintensities, independent of chronological age.
      Jiménez-Conde J; Jaume R; Elisa CG; Eva GS[43] Global DNA methylation Genome-wide b-Age is a crucial biomarker for predicting stroke recurrence, with higher b-age associated with elevated risk.
      * These top 10 most cited authors were extracted from Supplementary Table S2b. ABI3: ABI family member 3, ALLC: allantoicase, ALOX12: arachidonate 12-lipoxygenase 12S type, b-Age: biological age, MAP3K1: mitogen-activated protein kinase kinase kinase 1, PPM1A: protein phosphatase, Mg2+/Mn2+ dependent 1A, THBS2: thrombospondin-2, TRAF3: tumor necrosis factor receptor-associated factor 3, protein phosphatase, ZFP57: zinc finger protein 57 homolog, TGF-β1: transforming growth factor beta 1, ZFHX3: Zinc finger homeobox 3.

      Table 1. 

      Genetic loci associated with ischemic stroke identified in research articles published by the top 10 most cited leading authors.