[1]

Ren K, Han BQ, Lv LJ, Zhang GJ, Lei LJ, et al. 2019. Non-camellia Tea in China: Traditional usage, phytochemistry, and pharmacology. Chinese Herb Medicine 11:119−31

doi: 10.1016/j.chmed.2019.04.001
[2]

An Editorial Committee of the Administration Bureau of Traditional Chinese Medicine. 2004. Chinese Materia Medica (Zhonghua Bencao). Shanghai, China: Shanghai Science & Technology Press. pp. 200−18

[3]

Department of Biology Beijing Normal University. 1984. Flora of Beijing. Beijing: Beijing Press. pp. 819, 821

[4]

Li HW, Hedge IC. 1994. Scutellaria Linnaeus, Sp. Pl. 2: 598. 1753. In Flora of China. Beijing: Science Press and St. Louis: Missouri Botanical Garden Press. pp 75-103.

[5]

He CN, Peng Y, Xiao W, Li MH, Cui ZH, et al. 2011. Application history and research status of Huang-qin Tea. Modern Chinese Medcine 13(6):3−7

doi: 10.13313/j.issn.1673-4890.2011.06.005
[6]

Shen J, Li P, Liu S, Liu Q, Li Y, et al. 2020. The chemopreventive effects of Huangqin-tea against AOM-induced preneoplastic colonic aberrant crypt foci in rats and omics analysis. Food & Function 11:9634−50

doi: 10.1039/d0fo01731k
[7]

Li MR, Zhou YZ, Chai JX, Chen Q, Gao L, et al. 2020. The anti-aging effects of different parts of Scutellaria baicalensis Georgi based on 1H NMR urine metabolomics. Acta Pharmaceutica Sinica 55:2702−12

doi: 10.16438/j.0513-4870.2020-0865
[8]

Bi W, He C, Ma Y, Shen J, Zhang LH, et al. 2016. Investigation of free amino acid, total phenolics, antioxidant activity and purine alkaloids to assess the health properties of non-Camellia tea. Acta Pharmaceutica Sinica B 6:170−81

doi: 10.1016/j.apsb.2015.11.003
[9]

Feng X, Zhou YZ, Chai JX, Chen Q, Gao L, et al. 2020. Scutellaria baicalensis Georgi leaf and tea extracts prolong lifespan and alter the metabolomic aging profile in a Drosophila melanogaster aging model. Acta Pharmaceutica Sinica 55:1214−21

doi: 10.16438/j.0513-4870.2019-0884
[10]

Tang M, Dai SL, Zhou LS, Shao SY, Yan BF. 2022. Effect of total flavonoids in Scutellaria baicalensis stem-leaf on apoptosis, migration and invasion of colon cancer cells. Drug Evaluation Research 45:902−8

[11]

Ding SK, Liu QQ, Shang YZ. 2022. The effects and regulatory mechanism of flavonoids from stems and leaves of Scutellaria baicalensis Georgi in promoting neurogenesis and improving memory impairment mediated by the bdnf-erk-creb signaling pathway in rats. CNS & Neurological Disorders - Drug Targets 21:354−66

doi: 10.2174/1871527320666210827112048
[12]

He C, Peng Y, Xiao W, Li M, Cui Z, et al. 2011. Application history and research status of Huangqin tea. Modern Chinese Medicine 13:3−7

[13]

Liu G, Rajesh N, Wang X, Zhang M, Wu Q, et al. 2011. Identification of flavonoids in the stems and leaves of Scutellaria baicalensis Georgi. Journal of Chromatography B 879:1023−28

doi: 10.1016/j.jchromb.2011.02.050
[14]

Guo XY. 2015. Study on flavonoids from the stems and leaves of Scutellaria baicalensis Georgi. Thesis. Chengde Medical College, Hebei Province, China. pp. 55−78.

[15]

Wang HY, Han JX, Xu SX, Chen YJ, Wang ZH, et al. 2002. Flavonoids of the stems and leaves of Scutellaria baicalensis Georgi as ligands of the GABA(A) receptor benzodiazepine binding site. Chinese Journal of Medicina Chemistry 5:19−21

[16]

Wang HW, Yin ZF, Li HB, Yuan XX, Yang MM, et al. 2016. Chemical constituents from stems and leaves of Scutellaria baicalensis. Chinese Journal of Experimental Traditional Medical Formulae 22:41−44

doi: 10.13422/j.cnki.syfjx.2016220041
[17]

Zhao BY. 2012. Study on chemical constituents of the aerial parts of Scutellaria baicalensis Georgi. Thesis. Qiqihar University, Qiqihar, China. pp. 66−78.

[18]

Shen J, Li P, He CN, Liu HT, Liu YZ, et al. 2019. Simultaneous determination of 15 flavonoids from different parts of Scutellaria baicalensis and its chemometrics analysis. Chinese Herbal Medicines 11:20−27

doi: 10.1016/j.chmed.2018.09.005
[19]

Luo RR, Liu WD, Deng LL, Shen L, Cheng R, Sheng JP. 2013. Optimized extraction of total flavonoids from stems and leaves of Scutellaria by response surface methodology. Journal of Food Safety & Quality 4:1865−72

[20]

Takido M, Aimi M, Yamanouchi S, Yasukawa K, Torii H, et al. 1976. Studies on the constituents in the water extracts of crude drugs II. on the leaves of Scutellaria baicalensis Georgi. (1). Yakugaku Zasshi 96:381−83

doi: 10.1248/yakushi1947.96.3_381
[21]

Yukinori M, Yoshitaka I, Hiroyuki S, Tsuyoshi T. 1988. studies on the constituents of Scutellaria species (x): on the flavonoid constituents of the leaves of Scutellaria baicalensis Georgi. Shoyakugaku Zassh 42:216−19

[22]

Ma JL. 2013. Study on chemical composition of stems and leavesof Scutellaria baicalensis Georgi. Chinese Journal of Experimental Traditional Medical Formulae 19:147−49

[23]

Liu HO. 2016. Chemical composition and pharmacological activities of Scutellaria amoena. Thesis. Yunnan University of Traditional Chinese Medicine, China. pp. 346−67

[24]

Zhang H, Song X, Zhang N, Wu G, Wang Z, et al. 2011. Chemical composition study of Scutellaria scordifolia. Journal of Medicine & Pharmacy of Chinese Minorities 17:44−46

doi: 10.16041/j.cnki.cn15-1175.2011.02.036
[25]

Yang JJ. 2021. Study on the accumulation of active ingredients and formation of medicinal quality in Scutellaria baicalensis and Scutellaria viscidula. Thesis. Shaanxi Normal University, China. pp. 346−67

[26]

Wang X, Zhou X, Bai Y, Zhang C, Ren X. 2015. Determination of scutellarin content in the roots, stems, leaves, and flowers of Scutellaria scordifolia by HPLC. Journal of Medicine & Pharmacy of Chinese Minorities 21:56−57

[27]

Takeoka GR, Rodriguez DM, Dao L, Patterson R. 2009. Headspace volatiles of Scutellaria baicalensis Georgi flowers. Journal of Essential Oil Bearing Plants 12:435−42

doi: 10.1080/0972060X.2009.10643741
[28]

Gong J, Ni SF, Liu YZ, Wang ZF, Wang YC, et al. 2009. Study on the volatile oil from aerial part of Scutellaria baicalensis Georgi by GC-MS. Journal of Anhui Agricultural Sciences 37(32):15844−45

doi: 10.3969/j.issn.0517-6611.2017.31.043
[29]

Lu JJ, Xia Q, Liu SJ, Pan CG, Li Y. 2017. Comparative analysis of volatile components from above-ground part and underground part of Scutellaria baicalensis Georgi by GC-MS. Journal of Anhui Agricultural Sciences 45:137−138+147

[30]

Lawson SK, Satyal P, Setzer WN. 2021. Phytochemical analysis of the essential oils from aerial parts of four Scutellaria "Skullcap" species cultivated in South Alabama: Scutellaria baicalensis Georgi, S. Barbata D. Don, S. Incana Biehler, and S. Lateriflora L. Natural Product Communications 16(8):1−12

doi: 10.1177/1934578x211025930
[31]

Wang XD, Shi SL, Ma YZ. 2022. Determination of essential oil from Scutellaria baicalensis Georgi (Lamiaceae) by GC-MS, and assessment of its insecticidal properties. Tropical Journal of Pharmaceutical Research 21:1249−54

doi: 10.4314/tjpr.v21i6.17
[32]

Song SH, Wang ZZ. 2010. Analysis of essential oils from different organs of Scutellaria baicalensis. Journal of Chinese Medicinal Materials 33:1265−70

[33]

Zgórka G, Hajnos A. 2003. The application of solid-phase extraction and reversed phase high-performance liquid chromatography for simultaneous isolation and determination of plant flavonoids and phenolic acids. Chromatographia 57:S77−S80

doi: 10.1007/BF02492087
[34]

Chirikova NK, Olennikov DN. 2008. Composition of the aerial part of Scutellaria baicalensis. Chemistry of Natural Compounds 44:361−62

doi: 10.1007/s10600-008-9062-7
[35]

Hussein AA, de la Torre MC, Jimeno ML, Rodríguez B, Bruno M, et al. 1996. A neo-clerodane diterpenoid from Scutellaria baicalensis. Phytochemistry 43:835−37

doi: 10.1016/0031-9422(96)00380-9
[36]

Yuan BY, Yang ZX, Wan HX, Yuan H. 1998. Determination of metallic elements in different parts of Scutellaria baicalensis Georgi. Studies of Trace Elements and Health 15(4):43−45

[37]

Yan BF, Fu YX, Su SL, Yan H, Wu CY, et al. 2018. Simultaneous determination of inorganic elements in stems and leaves of Scutellaria baicalensis from different regions by ICP-MS. Chinese Traditional and Herbal Drugs 49(22):5418−25

[38]

Olennikov DN, Chirikova NK, Tankhaeva LM. 2008. Lamiaceae carbohydrates. IV. Water-soluble polysaccharides from Scutellaria baicalensis. Chemistry of Natural Compounds 44:556−59

doi: 10.1007/s10600-008-9147-3
[39]

Yan BF, Zhu SQ, Su SL, Zhu ZH, Guo S, et al. 2018. Simultaneous determination of amino acids in Scutellaria baicalensis stem-leaf from different habitats by UPLC-TQ-MS. Chinese Journal of Pharmaceutical Analysis 38:1165−73

[40]

EghbaliFeriz S, Taleghani A, Tayarani-Najaran Z. 2018. Central nervous system diseases and Scutellaria: A review of current mechanism studies. Biomedicine & Pharmacotherapy 102:185−95

doi: 10.1016/j.biopha.2018.03.021
[41]

Tong JM, Su GL, Fu JC, Tong Y. 1999. Research on the anti-inflammatory and antipyretic effects of total flavonoid from the stems and leaves of Scutellaria baicalensis. Chinese Journal of Ethnomedicine and Ethnopharmacy 8(5):287−288+310

[42]

Zhou XX, Li ST, Zhou XH, Wang CY. 2000. Experimental study on anti-inflammatory effects of total flavonoids from Scutellaria baicalensis stem and leaves. Chinese Journal of Information on Traditional Chinese Medicine 4:27−28

[43]

Zhao TH, Gao W, Yang HS, Deng SH, Shi YH, et al. 2001. Experimental study on anti-inflammatory effects of total flavonoids from Scutellaria baicalensis stem and leaves. Chinese Journal of Traditional Medical Science and Technology 3:173−74

[44]

Wang W, Bai Y, Wang J, Jiang DJ. 2009. Study on the anti-inflammatory mechanism of total flavonoids from Scutellaria baicalensis stems and leaves on rat synovitis induced by carrageenan. Chinese Medical Journal of Metallurgical Industry 26:460

[45]

Yang ZJ, Li J, Yang XJ, Geng GQ, Deng Y. 2015. Anti-inflammatory effect on stems and leaves of Scutellaria baicalensis from different areas of Gansu Province. Pharmacology and Clinics of Chinese Materia Medica 31:153−55

[46]

Liu JX, Deng SH, Yang HS, Shi YH, Gao W, et al. 2002. A study on ant-inflammatory effects mechanism of total flavone of Scutellaria stem and leaf. Chinese Pharmacological Bulletin 18(6):713−14

[47]

Feng GY, Song HR, Xing EH, Guo YC, Zhao T, et al. 2014. The regulatory effects of Scutellaria baicalensis stem -leaf total flavonoid on Th1/Th2 cells balance in mouse with collagen-induced arthritis. Immunological Journal 30:525−28

[48]

Wang YM, Liu YP, Cao K, Shang YZ. 2011. Effects of flavonoids from Scutellaria stems and leaves on memory impairment and nerve inflammation in chronic cerebral ischemia rats. Chinese Journal of Pharmacology and Toxicology 25:135−40

[49]

Xia YT, Chan GKL, Wang HY, Dong TTX, Duan R, et al. 2020. The anti-bacterial effects of aerial parts of Scutellaria baicalensis: Potential application as an additive in aquaculture feedings. Aquaculture 526:735418

doi: 10.1016/j.aquaculture.2020.735418
[50]

Zhao B, Yang XY, Qu XL, Duan GJ, Wang Q, et al. 2022. Scutellaria baicalensis Georgi stems and leaves improve acute pleurisy in rats by inhibiting TRPV1 pathway. China Academic Journal Electronic Publishing House 38:111−16

doi: 10.13412/j.cnki.zyyl.20220418.002
[51]

Zhao B, Duan GJ, Qu XL, Wei PF, Wang B, et al. 2022. Effect of Scutellaria baicalensis stem-leaf combined with Morus alba on TRPV1 signaling protein in rats with acute pneumonia induced by lipopolysaccharide. Central South Pharmacy 20:14−20

[52]

Yan BF, Liu J, Duan JA, Liu SJ, Zeng QQ, Fu YX. 2020. Study on potential mechanism of Scutellaria baicalensis stem-leaf to COVID-19 based on ultra high performance liquid chromatography and network pharmacology. Drug Evaluation Research 43:991−1002

[53]

Zhao TH, Deng SH, Yang HS, Chen SP. 2007. Study of antibacterial activity of active fraction from stems and leaves of Scutellaria baicalensis Georgi. Chinese Pharmacological Bulletin 23(7):882−86

[54]

Zhang L, Su XR, Xu Y, Xu LJ, Zhu Z, et al. 2019. Combination of stem and leave of Scutellaria baicalensis and Ampelopsis grossedentata increases their antibacterial efficacy. Natural Product Research and Development 31:380−86

doi: 10.16333/j.1001-6880.2019.3.002
[55]

Zhao TH, Chen SP, Yang HS, Deng SH, Gao W. 2006. Antiviral effects of active fraction from stems and leaves of Scutellaria baicalensis. Journal of China Pharmaceutical University 37(6):544−47

[56]

Zhang F, Guo ZH, Sun J. 2006. Antipyretic effect of scutellarin abstracted from stems and leaves of Scutellaria baicalensis. Progress of Anatomical Sciences 3:227−28

doi: 10.16695/j.cnki.1006-2947.2006.03.012
[57]

Yang HS, Meng YB, Liu YH, Zhao TH. 2006. The effect of total flavonoids from Scutellaria baicalensis stems and leaves on infectious fever response in rats. Journal of Chengde Medical College 23:194

doi: 10.15921/j.cnki.cyxb.2006.02.050
[58]

Yang HS, Liu YH, Liu YH, Deng SH. 2010. Inhibition effect of total flavonoids from Scutellaria baicalensis stems and leaves on thermal-induced pain response in mice. Journal of Chengde Medical College 27:439

doi: 10.15921/j.cnki.cyxb.2010.04.014
[59]

Zhao TH, Yang HS, Deng SH, Gao W, Shi YH, et al. 2001. Experimental study on the analgesic effect of total flavonoids from Scutellaria baicalensis stems and leaves. Chinese Journal of Traditional Medical Science and Technology 3:175−77

[60]

Lv G, Cui B, Lan H, Wen Y, Sun A, et al. 2015. Diarylethene based fluorescent switchable probes for the detection of amyloid-β pathology in Alzheimer's disease. Chemical Communications 51:125−28

doi: 10.1039/C4CC07656G
[61]

Ye H, Wang RT, Zuo YZ, Guan LH, Shen XB. 2009. The effect of total flavonoids of Scutellaria baicalensis stem and leaf against learning and memory deficit induced by Aβ25-35 injection in rat hippocampus. Lishizhen Medicine and Materia Medica Research 20:879−80

[62]

Wang RT, Shen XB, Zhou J, Guan LH, Zhang JX. 2010. Effect of total flavonoids from scutellarea baicalensis stem-leaf on hippocampal injury induced by bilateral injection of Aβ25-35 in rats. Chinese Journal of New Drugs 19(11):982−85

[63]

Wang RT, Guan LH, Zhou J, Shen XB, Zhang JX. 2011. Effect of Scutellaria baicalensis stem-leaf total flavonoid on learning and memory impairment induced by Aβ25-35 and activity of anti-oxidative enzyme of hippocampus in rats. Acta Neuropharmacologica 1:14−18

[64]

Wang RT, Dong YJ, Zuo YJ, Guan LH, Ding S. 2016. Effect of total flavonoids from Scutellaria baicalensis stem and leaf on Bax and Bcl-2 protein expression in hippocampal neurons of Alzheimer's disease rats. Chinese Journal of Gerontology 36:2337−40

[65]

Cheng JJ, Zhao HX, Guo K, Miao H, Ma S, et al. 2016. Flavonoid from Scutellaria stems and leaves attenuates composited Aβ-induced memory impairment and apoptosis in rats. Chinese Journal of New Drugs 25:2627−36

[66]

Ding SK, Shang YZ. 2022. Flavonoids from stems and leaves of Scutellaria baicalensis Georgi regulate the brain tau hyperphosphorylation at multiple sites induced by composited Aβ in rats. CNS and Neurological Disorders - Drug Targets 21:367−74

doi: 10.2174/1871527320666210827112609
[67]

Liu QQ, Ding SK, Zhang H, Shang YZ. 2022. The molecular mechanism of Scutellaria baicalensis Georgi stems and leaves flavonoids in promoting neurogenesis and improving memory impairment by the PI3K-AKT-CREB signaling pathway in rats. Combinatorial Chemistry & High Throughput Screening 25:919−33

doi: 10.2174/1386207324666210506152320
[68]

Zhang SF, Dong YC, Zhang XF, Wu XG, Cheng JJ, et al. 2015. Flavonoids from Scutellaria attenuate okadaic acid-induced neuronal damage in rats. Brain Injury 29:1376−82

doi: 10.3109/02699052.2015.1042053
[69]

Cao YJ, Liang LZ, Xu J, Wu JL, Yan YX, et al. 2016. The effect of Scutellaria baicalensis stem-leaf flavonoids on spatial learning and memory in chronic cerebral ischemia-induced vascular dementia of rats. Acta Biochimica et Biophysica Sinica 48:437−46

doi: 10.1093/abbs/gmw024
[70]

Gao Y, Wang XQ, Ma S, Dong YC, Shang YZ. 2021. Flavonoids from stem and leaf of Scutellaria baicalensis georgi inhibit the phosphorylation on multi-sites of tau protein induced by okadaic acid and the regulative mechanism of protein kinases in rats. Combinatorial Chemistry & High Throughput Screening 24:1126−36

doi: 10.2174/1386207323666200901101233
[71]

Xu C, Ye Y, Li C, Shang Y. 2023. The effects and mechanism of Scutellaria baicalensis Georgi stems and leaves flavonoids on myelin sheath degeneration iinduced by composited Aβ in rats. CNS & Neurological Disorders Drug Targets 23(4):504−11

doi: 10.2174/1871527322666230510103540
[72]

Li XL, Xu XF, Bu QX, Jin WR, Sun QR, et al. 2016. Effect of total flavonoids from Scutellaria baicalensis on dopaminergic neurons in the substantia nigra. Biomedical Reports 5:213−16

doi: 10.3892/br.2016.713
[73]

Yang S, Wang H, Yang Y, Wang R, Wang Y, et al. 2019. Baicalein administered in the subacute phase ameliorates ischemia-reperfusion-induced brain injury by reducing neuroinflammation and neuronal damage. Biomedicine & Pharmacotherapy 117:119102

doi: 10.1016/j.biopha.2019.109102
[74]

Wang L, Chen W, Li M, Zhang F, Chen K, et al. 2020. A review of the ethnopharmacology, phytochemistry, pharmacology, and quality control of Scutellaria barbata D. Don. Journal of Ethnopharmacology 254:112260

doi: 10.1016/j.jep.2019.112260
[75]

Zhao SM, Yang HG, Kong XY, Song CJ, Liu YP. 2006. Effects of pretreatment with total flavonoids from stems and leaves of Scutellaria baicalensis george on activity of superoxide dismutase and level of malondialdehyde in ischemia-reperfusion myocardium. Chinese Journal of Clinical Rehabilitation 10(31):52−54

[76]

Zhao SM, Kong W, Zhang SF, Chen M, Zhang XY, et al. 2011. The Effects of Stem-leaf Total Flavonoid on the Apoptosis Protein Expression and Ultrastructural Changes of Ischemia Reperfusion Damaged Neuron. Acta Neuropharmacologica 1:19−26

[77]

Yu XM, Hao XJ, Gong MY. 2010. Effect of Scutellaria baicalensis stem-leaf total flavonoid on myocardial apoptosis and janus kinases 2 protein expression during ischemia reperfusion in rats. Chinese Journal of Experimental Traditional Medical Formulae 16:116−19

doi: 10.13422/j.cnki.syfjx.2010.16.045
[78]

Wang YM, Liu YP, Kai C, Qin BW, Shang YZ. 2012. The effects of flavonoids from Scutellaria stem and leaf on the expression of NMDAR and VEGF in chronic cerebral ischemia rats. Chinese Journal of Pathophysiology 28(2):353−57

[79]

Zhao SM, Kong W, Zhang SF, Chen M, Zheng XY, et al. 2013. Pretreatment with Scutellaria baicalensis stem-leaf total flavonoid prevents cerebral ischemia-reperfusion injury. Neural Regeneration Research 8:3183−92

doi: 10.3969/j.issn.1673-5374.2013.34.002
[80]

Shang YZ, Zhang H, Cheng JJ, Miao H, Liu YP, et al. 2013. Flavonoids from Scutellaria baicalensis georgi are effective to treat cerebral ischemia/reperfusion. Neural Regeneration Research 8:514−22

doi: 10.3969/j.issn.1673-5374.2013.06.004
[81]

Kong XY, Kong W, Miao GX, Zhao SM, Chen M, et al. 2014. Pretreatment with Scutellaria baicalensis stem-leaf total flavonoid protects against cerebral ischemia/reperfusion injury in hippocampal neurons. Neural Regeneration Research 9:2066−73

doi: 10.4103/1673-5374.147933
[82]

Bai JT, Gong L, Zhao SM, Han. 2015. Role of SSTF in protecting ultrastructure of cerebral cortexneurons and synapse in rats following I/R injury. Chinese Journal of Geriatric Heart Brain and Vessel Diseases 17:1091−93

[83]

Yan P, Liu YD, Kong XY, Zhao SM. 2016. Protective effects on microvessels injury and oxidative stress of cerebral cortex in ischemia reperfusion injured by pretreatment with Scutellaria baicalensis stem-leaf total flavonoid. MedicalResearch and Education 33:12−7+35

[84]

Li YQ, Xu ZW, Zhao XZ, Kang SX, Cui HG. 2022. Effect of intragastric administration of Huangqin (Scutellaria baicalensis Georgi) on myocardial remodeling and NF-κB expression in rats with primary hypertension. Shandong Medical Journal 62:39−42

[85]

Song J, Zhou YZ, Pang YY, Gao L, Du GH, et al. 2020. The anti-aging effect of Scutellaria baicalensis Georgi flowers extract by regulating the glutamine-glutamate metabolic pathway in D-galactose induced aging rats. Experimental Gerontology 134:110843

doi: 10.1016/j.exger.2020.110843
[86]

Pang YY, Zhou YZ, Song J, Du GH, Qin XM. 2020. Anti-aging effect of Scutellaria baicalensis Georgi leaves based on 1H NMR serum and liver metabolomics. Acta Pharmaceutica Sinica 55:74−82

doi: 10.16438/j.0513-4870.2019-0377
[87]

Feng GY, Xing EH, Song HR, Guo YC, Zhao T, et al. 2014. Effects of the Scutellaria baicalensis stem-leaf total flavonoid on the Th17 and Treg cells of mouse with collagen-induced arthritis. Lishizhen Medicine Materia Medica Research 25:547−49

[88]

Zhang FY, Zhang B, Shen RW, Xu X, Guo LL, et al. 2016. The Scutellaria baicalensis stem-leaf total flavonoid regulate the balance of Th17/Treg in EAE rats. Immunological Journal 32:884−89

doi: 10.13431/j.cnki.immunol.j.20160172
[89]

Zhang F, Zhang B, Shen R, Xu X, Guo L, et al. 2017. The Scutellaria baicalensis stem-leaf total flavonoid regulates the balance of Th17/Treg in EAE rats. International Journal of Clinical and Experimental Medicine 10(2):2408−18

[90]

Guo HF, Xu Q. 2013. Effects Of Scutellaria baicalensis stem-leaf total flavonoid on proliferation of hela cells. Journal of Chengde Medical College 30:275−77

doi: 10.15921/j.cnki.cyxb.2013.04.019
[91]

Chen JB, Chen YN, Zhuang X, Feng PP, Yang F, et al. 2019. Role of Scutellaria baicalensis stem-leaf total flavonoid in regulating blood lipid level of rats with hypertriglyceridemia. Journal of Clinical Medicine in Practice 23:70−73

[92]

Gutteridge JMC. 1994. Biological origin of free radicals, and mechanisms of antioxidant protection. Chemico-Biological Interactions 91:133−40

doi: 10.1016/0009-2797(94)90033-7
[93]

Guan LH, Qin BW, Shang YZ. 2013. Flavonoid extract from stem and leaf of Scutellaria baicalensis Georgi attenuates H2O2-induced oxidative damages in rat cortical neurons. Chinese Journal of New Drugs 22:837−41

[94]

Vergun O, Svydenko L, Grygorieva O, Shymanska O, Rakhmetov D, et al. 2019. Antioxidant capacity of plant raw material of Scutellaria baicalensis Georgi. Potravinarstvo Slovak Journal of Food Sciences 13:614−21

doi: 10.5219/1090
[95]

Liu Y, Cao K, Miao H, Cheng J, Shang Y. 2011. Flavonoids from the stems and leaves of Scutellaria baicalensis Georgi attenuate H2O2-induced oxidative damage to rat cortical neurons. Neural Regeneration Research 6:2100−4

[96]

Cao ZC, Zhou XX, Pang SH, Tan JC, Su PQ. 2013. Study on the protective effect and mechanism of SSTF on human umbilical vascular endothelial cells oxidative injury induced by H2O2. Journal of Clinical Medicine in Practice 17:1−3+7

[97]

Zhou XX, Su PQ, Liu Z. 2006. Experimental study of total flavonoids from stems and leaves of Scatellaria baicalensis in preventing and curing diabetes mellitus. Traditional Chinese Drug Research Clinical Pharmacology 17(6):418−20

doi: 10.19378/j.issn.1003-9783.2006.06.007
[98]

Liu Z, Zhou X, Su P, Zhu W. 2009. Experimental study of total flavonoids from stem-leaf of Scutellaria baicalensis in treating type 2 diabetic hyperlipidemia. Traditional Chinese Drug Research Clinical Pharmacology 20:5−7

doi: 10.19378/j.issn.1003-9783.2009.01.002
[99]

Yang HM, Li SM, Mei LX, Ma CH. 2006. Effects of Scutellaria baicalensis stem-leaf total flavonoid on the activation of hepatic stellate cells. Journal of Basic Chinese Medicine 12(1):42−44

[100]

Li ST, Yang HM, Shi YH, Gong MY. 2004. Study on liver-protection of Scutellaria baicalensis stem-leaf total flavonoid. Chinese. Journal of Information on Traditional Chinese Medicine 11(7):593−94

[101]

Tong JM, Liu YL, Fu JG. 1999. Study on long-term toxicities of total flavonoid from stems and leaves of Scutellaria baicalensis. Journal of Chengde Medical College 16:10−13

[102]

Yuan M, Zhao TH, Yang SH, Gao W, Deng SH, et al. 2002. Study on acute toxicity of Scutellaria baicalensis stem and leaf flavonoids capsule. Hebei Medicine 8(7):669−70

[103]

Liu DW, Cai M, Wu JM, Qu L. 2020. Toxicological tests on safety assessment of Scutellaria baicalensis stem-leaf aqueous extract. Drug Evaluation Research 43:2233−40