[1]

Porter RJ, Kalla R, Ho GT. 2020. Ulcerative colitis: recent advances in the understanding of disease pathogenesis. F1000Research 0:294

doi: 10.12688/f1000research.20805.1
[2]

Kobayashi T, Siegmund B, Le Berre C, Wei SC, Ferrante M, et al. 2020. Ulcerative colitis. Nature Reviews Disease Primers 6:74

doi: 10.1038/s41572-020-0205-x
[3]

Harbord M, Eliakim R, Bettenworth D, Karmiris K, Katsanos K, et al. 2017. Third european evidence-based consensus on diagnosis and management of ulcerative colitis. Part 2: current management. Journal of Crohn's and Colitis 11:769−84

doi: 10.1093/ecco-jcc/jjx009
[4]

Sandborn WJ, Panés J, Sands BE, Reinisch W, Su C, et al. 2019. Venous thromboembolic events in the tofacitinib ulcerative colitis clinical development programme. Alimentary Pharmacology & Therapeutics 50:1068−76

doi: 10.1111/apt.15514
[5]

Nishida A, Inoue R, Inatomi O, Bamba S, Naito Y, et al. 2018. Gut microbiota in the pathogenesis of inflammatory bowel disease. Clinical Journal of Gastroenterology 11:1−10

doi: 10.1007/s12328-017-0813-5
[6]

Zhao Y, Li M, Wang Y, Geng R, Fang J, et al. 2023. Understanding the mechanism underlying the anti-diabetic effect of dietary component: a focus on gut microbiota. Critical Reviews in Food Science and Nutrition 63:7378−98

doi: 10.1080/10408398.2022.2045895
[7]

Gallimore AM, Godkin A. 2013. Epithelial barriers, microbiota, and colorectal cancer. The New England Journal of Medicine 368:282−84

doi: 10.1056/NEJMcibr1212341
[8]

Ansari M, Emami S. 2016. β-ionone and its analogs as promising anticancer agents. European Journal of Medicinal Chemistry 123:141−54

doi: 10.1016/j.ejmech.2016.07.037
[9]

Zhu Q, Tong T. 2023. Research progress on bioactivities of β-ionone and structure-function relationship of its derivatives. Journal of Food Safety and Quality 14:101−8

[10]

Kamada K, Yasuda R, Murakami T, Inoue R, Mizushima K, et al. 2020. Tu1927 the effects of carotenoid ingestion on the expression of tight junction protein in intestine which were correlated with gut microbiota composition. Gastroenterology 158:S1221−S1222

doi: 10.1016/s0016-5085(20)33714-8
[11]

Ma Y, Guo X, Wang Q, Liu T, Liu Q, et al. 2022. Anti-inflammatory effects of β-ionone-curcumin hybrid derivatives against ulcerative colitis. Chemico-Biological Interactions 367:110189

doi: 10.1016/j.cbi.2022.110189
[12]

Xiong T, Zheng X, Zhang K, Wu H, Dong Y, et al. 2022. Ganluyin ameliorates dss-induced ulcerative colitis by inhibiting the enteric-origin LPS/TLR4/NF-κB pathway. Journal of Ethnopharmacology 289:115001

doi: 10.1016/j.jep.2022.115001
[13]

Wang X, Yang J, Cao Q, Tang J. 2014. Therapeutic efficacy and mechanism of water-soluble extracts of banxiaxiexin decoction on BALB/C mice with oxazolone-induced colitis. Experimental and Therapeutic Medicine 8:1201−4

doi: 10.3892/etm.2014.1890
[14]

Krych Ł, Kot W, Bendtsen KMB, Hansen AK, Vogensen FK, et al. 2018. Have you tried spermine? A rapid and cost-effective method to eliminate dextran sodium sulfate inhibition of PCR and RT-PCR. Journal of Microbiological Methods 144:1−7

doi: 10.1016/j.mimet.2017.10.015
[15]

Chassaing B, Koren O, Goodrich JK, Poole AC, Srinivasan S, et al. 2015. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature 519:92−96

doi: 10.1038/nature14232
[16]

Nearing JT, Douglas GM, Hayes MG, MacDonald J, Desai DK, et al. 2022. Microbiome differential abundance methods produce different results across 38 datasets. Nature Communications 13:342

doi: 10.1038/s41467-022-28034-z
[17]

El-Akabawy G, El-Sherif NM. 2019. Zeaxanthin exerts protective effects on acetic acid-induced colitis in rats via modulation of pro-inflammatory cytokines and oxidative stress. Biomedicine & Pharmacotherapy 111:841−51

doi: 10.1016/j.biopha.2019.01.001
[18]

Jeon YD, Lee JH, Lee YM, Kim DK. 2020. Puerarin inhibits inflammation and oxidative stress in dextran sulfate sodium-induced colitis mice model. Biomedicine & Pharmacotherapy 124:109847

doi: 10.1016/j.biopha.2020.109847
[19]

Kwon J, Lee C, Heo S, Kim B, Hyun CK. 2021. Dss-induced colitis is associated with adipose tissue dysfunction and disrupted hepatic lipid metabolism leading to hepatosteatosis and dyslipidemia in mice. Scientific Reports 11:5283

doi: 10.1038/s41598-021-84761-1
[20]

Pelaseyed T, Bergström JH, Gustafsson JK, Ermund A, Birchenough GMH, et al. 2014. The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system. Immunological Reviews 260:8−20

doi: 10.1111/imr.12182
[21]

Gong Y, Li H, Li Y. 2016. Effects of Bacillus subtilis on epithelial tight junctions of mice with inflammatory bowel disease. Journal of Interferon and Cytokine Research 36:75−85

doi: 10.1089/jir.2015.0030
[22]

Dahl C, Stigum H, Valeur J, Iszatt N, Lenters V, et al. 2018. Preterm infants have distinct microbiomes not explained by mode of delivery, breastfeeding duration or antibiotic exposure. International Journal of Epidemiology 47:1658−69

doi: 10.1093/ije/dyy064
[23]

Hu Y, Ye Z, Wu M, She Y, Li L, et al. 2021. The communication between intestinal microbiota and ulcerative colitis: an exploration of pathogenesis, animal models, and potential therapeutic strategies. Frontiers in Medicine 8:766126

doi: 10.3389/fmed.2021.766126
[24]

Peng L, Gao X, Nie L, Xie J, Dai T, et al. 2020. Astragalin attenuates dextran sulfate sodium (DSS)-induced acute experimental colitis by alleviating gut microbiota dysbiosis and inhibiting NF-κB activation in mice. Frontiers in Immunology 11:2058

doi: 10.3389/fimmu.2020.02058
[25]

Moura FA, de Andrade KQ, de Araújo ORP, Nunes-Souza V, de Farias Santos JC, et al. 2016. Colonic and hepatic modulation by lipoic acid and/or n-acetylcysteine supplementation in mild ulcerative colitis induced by dextran sodium sulfate in rats. Oxidative Medicine and Cellular Longevity 2016:1−18

doi: 10.1155/2016/4047362
[26]

Agista AZ, Rusbana TB, Islam J, Ohsaki Y, Sultana H, et al. 2021. Fermented rice bran supplementation prevents the development of intestinal fibrosis due to DSS-induced inflammation in mice. Nutrients 13:1869

doi: 10.3390/nu13061869
[27]

Chen L, Yokoyama W, Alves P, Tan Y, Pan J, et al. 2021. Effect of encapsulation on β-carotene absorption and metabolism in mice. Food Hydrocolloids 121:107009

doi: 10.1016/j.foodhyd.2021.107009
[28]

Yin M, Li C, Zhang L, Zhang L, Lin J, et al. 2022. Mechanism of antifungal activity and therapeutic action of β-ionone on Aspergillus fumigatus keratitis via suppressing LOX1 and JNK/p38 MAPK activation. International Immunopharmacology 110:108992

doi: 10.1016/j.intimp.2022.108992
[29]

Fukuda T, Majumder K, Zhang H, Turner PV, Matsui T, et al. 2016. Adenine inhibits TNF-α signaling in intestinal epithelial cells and reduces mucosal inflammation in a dextran sodium sulfate-induced colitis mouse model. Journal of Agricultural and Food Chemistry 64:4227−34

doi: 10.1021/acs.jafc.6b00665
[30]

Shan M, Gentile M, Yeiser JR, Walland AC, Bornstein VU, et al. 2013. Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals. Science 342:447−53

doi: 10.1126/science.1237910
[31]

Wu Y, Jha R, Li A, Liu H, Zhang Z, et al. 2022. Probiotics (Lactobacillus plantarum HNU082) supplementation relieves ulcerative colitis by affecting intestinal barrier functions, immunity-related gene expression, gut microbiota, and metabolic pathways in mice. Microbiology Spectrum 10:e01651-22

doi: 10.1128/spectrum.01651-22
[32]

Edelblum KL, Turner JR. 2009. The tight junction in inflammatory disease: communication breakdown. Current Opinion in Pharmacology 9:715−20

doi: 10.1016/j.coph.2009.06.022
[33]

Li Q, Zhou S, Wang Y, Cong J. 2022. Changes of intestinal microbiota and microbiota-based treatments in IBD. Archives of Microbiology 204:442

doi: 10.1007/s00203-022-03069-4
[34]

Hu S, Ma Y, Xiong K, Wang Y, Liu Y, et al. 2023. Ameliorating effects of vitamin k2 on dextran sulfate sodium-induced ulcerative colitis in mice. International Journal of Molecular Sciences 24:2986

doi: 10.3390/ijms24032986
[35]

Fan Y, Pedersen O. 2021. Gut microbiota in human metabolic health and disease. Nature reviews. Microbiology 19:55−71

doi: 10.1038/s41579-020-0433-9
[36]

Tian M, Li D, Ma C, Feng Y, Hu X, et al. 2021. Barley leaf insoluble dietary fiber alleviated dextran sulfate sodium-induced mice colitis by modulating gut microbiota. Nutrients 13:846

doi: 10.3390/nu13030846
[37]

Cui L, Guan X, Ding W, Luo Y, Wang W, et al. 2021. Scutellaria baicalensis georgi polysaccharide ameliorates DSS-induced ulcerative colitis by improving intestinal barrier function and modulating gut microbiota. International Journal of Biological Macromolecules 166:1035−45

doi: 10.1016/j.ijbiomac.2020.10.259
[38]

Martens EC, Neumann M, Desai MS. 2018. Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier. Nature Reviews Microbiology 16:457−70

doi: 10.1038/s41579-018-0036-x
[39]

Guo J, Li M, Zhao Y, Kang SG, Huang K, et al. 2023. Dietary supplementation of cedryl acetate ameliorates adiposity and improves glucose homeostasis in high-fat diet-fed mice. Nutrients 15:980

doi: 10.3390/nu15040980
[40]

Tong T, Guo J, Wu Y, Sharma D, Sangar M, et al. 2024. Dietary supplementation of ark clams protects gut health and modifies gut microbiota in d-galactose-induced aging rats. Journal of the Science of Food and Agriculture 104:675−685

doi: 10.1002/jsfa.12958
[41]

Falony G, Joossens M, Vieira-Silva S, Wang J, Darzi Y, et al. 2016. Population-level analysis of gut microbiome variation. Science 352:560−564

doi: 10.1126/science.aad3503
[42]

Baldassano SN, Bassett DS. 2016. Topological distortion and reorganized modular structure of gut microbial co-occurrence networks in inflammatory bowel disease. Scientific Reports 6:26087

doi: 10.1038/srep26087
[43]

Nikolaus S, Schulte B, Al-Massad N, Thieme F, Schulte DM, et al. 2017. Increased tryptophan metabolism is associated with activity of inflammatory bowel diseases. Gastroenterology 153:1504−1516.E2

doi: 10.1053/j.gastro.2017.08.028
[44]

Zhang HL, Zhang AH, Miao JH, Sun H, Yan GL, et al. 2019. Targeting regulation of tryptophan metabolism for colorectal cancer therapy: a systematic review. RSC Advances 9:338−72

doi: 10.1039/c8ra08520j
[45]

Wu L, Tang Z, Chen H, Ren Z, Ding Q, et al. 2021. Mutual interaction between gut microbiota and protein/amino acid metabolism for host mucosal immunity and health. Animal Nutrition 7:11−16

doi: 10.1016/j.aninu.2020.11.003
[46]

Feng W, Liu J, Tan Y, Ao H, Wang J, et al. 2020. Polysaccharides from Atractylodes macrocephala koidz. Ameliorate ulcerative colitis via extensive modification of gut microbiota and host metabolism. Food Research International 138:109777

doi: 10.1016/j.foodres.2020.109777
[47]

Winkler ES, Thackray LB. 2019. A long-distance relationship: the commensal gut microbiota and systemic viruses. Current Opinion in Virology 37:44−51

doi: 10.1016/j.coviro.2019.05.009