| [1] |
Aghaali Z, Naghavi MR. 2024. Developing benzylisoquinoline alkaloid-enriched opium poppy via CRISPR-directed genome editing: a review. |
| [2] |
Hong UVT, Tamiru-Oli M, Hurgobin B, Lewsey MG. 2025. Genomic and cell-specific regulation of benzylisoquinoline alkaloid biosynthesis in opium poppy. |
| [3] |
He SM, Liang YL, Cong K, Chen G, Zhao X, et al. 2018. Identification and characterization of genes involved in benzylisoquinoline alkaloid biosynthesis in Coptis species. |
| [4] |
Ziegler J, Facchini PJ. 2008. Alkaloid biosynthesis: metabolism and trafficking. |
| [5] |
Sato F. 2013. Characterization of plant functions using cultured plant cells, and biotechnological applications. |
| [6] |
Takanashi K, Yamada Y, Sasaki T, Yamamoto Y, Sato F, et al. 2017. A multidrug and toxic compound extrusion transporter mediates berberine accumulation into vacuoles in Coptis japonica. |
| [7] |
Wang J, Wang L, Lou GH, Zeng HR, Hu J, et al. 2019. Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology. |
| [8] |
Aghaali Z, Naghavi MR, Zargar M. 2024. Promising approaches for simultaneous enhancement of medicinally significant benzylisoquinoline alkaloids in opium poppy. |
| [9] |
Yamada Y, Hirakawa H, Hori K, Minakuchi Y, Toyoda A, et al. 2021. Comparative analysis using the draft genome sequence of California poppy (Eschscholzia californica) for exploring the candidate genes involved in benzylisoquinoline alkaloid biosynthesis. |
| [10] |
Xu Z, Tian Y, Wang J, Ma Y, Li Q, et al. 2024. Convergent evolution of berberine biosynthesis. |
| [11] |
Xu T, Kuang T, Du H, Li Q, Feng T, et al. 2020. Magnoflorine: a review of its pharmacology, pharmacokinetics and toxicity. |
| [12] |
Zhong F, Chen Y, Chen J, Liao H, Li Y, Ma Y. 2022. Jatrorrhizine: A review of sources, pharmacology, pharmacokinetics and toxicity. |
| [13] |
Roth L, Adler M, Jain T, Bempong D. 2018. Monographs for medicines on WHO's model list of essential medicines. |
| [14] |
Altinoz MA, Topcu G, Hacimuftuoglu A, Ozpinar A, Ozpinar A, et al. 2019. Noscapine, a non-addictive opioid and microtubule-inhibitor in potential treatment of glioblastoma. |
| [15] |
Ashrafi S, Alam S, Sultana A, Raj A, Emon NU, et al. 2023. Papaverine: a miraculous alkaloid from opium and its multimedicinal application. |
| [16] |
Becker A, Yamada Y, Sato F. 2023. California poppy (Eschscholzia californica), the Papaveraceae golden girl model organism for evodevo and specialized metabolism. |
| [17] |
Malla RR, Bhamidipati P, Adem M. 2023. Insights into the potential of Sanguinarine as a promising therapeutic option for breast cancer. |
| [18] |
Kosina P, Walterová D, Ulrichová J, Lichnovský V, Stiborová M, et al. 2004. Sanguinarine and chelerythrine: assessment of safety on pigs in ninety days feeding experiment. |
| [19] |
Stöckigt J, Antonchick AP, Wu F, Waldmann H. 2011. The pictet-spengler reaction in nature and in organic chemistry. |
| [20] |
Ruiz-Olalla A, Würdemann MA, Wanner MJ, Ingemann S, van Maarseveen JH, et al. 2015. Organocatalytic enantioselective Pictet-Spengler approach to biologically relevant 1-benzyl-1,2,3,4-tetrahydroisoquinoline alkaloids. |
| [21] |
Min X, Zhu T, Hu X, Hou C, He J, et al. 2023. Transcriptome and metabolome analysis of isoquinoline alkaloid biosynthesis of Coptis chinensis in different years. |
| [22] |
Liu Y, Wang B, Shu S, Li Z, Song C, et al. 2021. Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids. |
| [23] |
Hori K, Yamada Y, Purwanto R, Minakuchi Y, Toyoda A, et al. 2018. Mining of the uncharacterized cytochrome P450 genes involved in alkaloid biosynthesis in California poppy using a draft genome sequence. |
| [24] |
Zhong F, Huang L, Qi L, Ma Y, Yan Z. 2020. Full-length transcriptome analysis of Coptis deltoidea and identification of putative genes involved in benzylisoquinoline alkaloids biosynthesis based on combined sequencing platforms. |
| [25] |
Xu T, Yang X, Jia Y, Li Z, Tang G, et al. 2022. A global survey of the transcriptome of the opium poppy (Papaver somniferum) based on single-molecule long-read isoform sequencing. |
| [26] |
Li Q, Ramasamy S, Singh P, Hagel JM, Dunemann SM, et al. 2020. Gene clustering and copy number variation in alkaloid metabolic pathways of opium poppy. |
| [27] |
Sunhe YX, Zhang YH, Fu RJ, Xu DQ, Tang YP. 2024. Neuroprotective effect and preparation methods of berberine. |
| [28] |
Shakeri F, Kiani S, Rahimi G, Boskabady MH. 2024. Anti-inflammatory, antioxidant, and immunomodulatory effects of Berberis vulgaris and its constituent berberine, experimental and clinical, a review. |
| [29] |
Askari VR, Khosravi K, Baradaran Rahimi V, Garzoli S. 2024. A mechanistic review on how berberine use combats diabetes and related complications: molecular, cellular, and metabolic effects. |
| [30] |
Khezri MR, Mohammadipanah S, Ghasemnejad-Berenji M. 2024. The pharmacological effects of Berberine and its therapeutic potential in different diseases: Role of the phosphatidylinositol 3-kinase/AKT signaling pathway. |
| [31] |
Lu Q, Tang Y, Luo S, Gong Q, Li C. 2023. Coptisine, the characteristic constituent from Coptis chinensis, exhibits significant therapeutic potential in treating cancers, metabolic and inflammatory diseases. |
| [32] |
Liu L, Li J, He Y. 2020. Multifunctional epiberberine mediates multi-therapeutic effects. |
| [33] |
Lei C, Yao Y, Shen B, Liu J, Pan Q, et al. 2019. Columbamine suppresses the proliferation and malignization of colon cancer cells via abolishing Wnt/β-catenin signaling pathway. |
| [34] |
Wang Y, Han Y, Chai F, Xiang H, Huang T, et al. 2016. The antihypercholesterolemic effect of columbamine from Rhizoma Coptidis in HFHC-diet induced hamsters through HNF-4α/FTF-mediated CYP7A1 activation. |
| [35] |
Tarabasz D, Kukula-Koch W. 2020. Palmatine: a review of pharmacological properties and pharmacokinetics. |
| [36] |
Badshah I, Anwar M, Murtaza B, Khan MI. 2024. Molecular mechanisms of morphine tolerance and dependence; novel insights and future perspectives. |
| [37] |
Singh A, Menéndez-Perdomo IM, Facchini PJ. 2019. Benzylisoquinoline alkaloid biosynthesis in opium poppy: an update. |
| [38] |
Rajecky M, Slaninova I, Mokrisova P, Urbanova J, Palkovsky M, et al. 2013. Alkaloid chelirubine and DNA: blue and red luminescence. |
| [39] |
Balažová A, Urdová J, Forman V, Mučaji P. 2020. Enhancement of macarpine production in Eschscholzia Californica suspension cultures under salicylic acid elicitation and precursor supplementation. |
| [40] |
Jiao X, Fu X, Li Q, Bu J, Liu X, et al. 2024. De novo production of protoberberine and benzophenanthridine alkaloids through metabolic engineering of yeast. |
| [41] |
Kaserer T, Steinacher T, Kainhofer R, Erli F, Sturm S, et al. 2020. Identification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists. |
| [42] |
Li Y, Zeng RJ, Chen JZ, Wu YB, Chou GX, et al. 2015. Pharmacokinetics and metabolism study of isoboldine, a major bioactive component from Radix Linderae in male rats by UPLC-MS/MS. |
| [43] |
De Sousa JPM, Oliveira NCSA, Fernandes PA. 2023. Rational engineering of (S)-norcoclaurine synthase for efficient benzylisoquinoline alkaloids biosynthesis. |
| [44] |
Yang M, Zhu L, Li L, Li J, Xu L, et al. 2017. Digital gene expression analysis provides insight into the transcript profile of the genes involved in aporphine alkaloid biosynthesis in Lotus (Nelumbo nucifera). |
| [45] |
Tjallinks G, Mattevi A, Fraaije MW. 2024. Biosynthetic strategies of berberine bridge enzyme-like flavoprotein oxidases toward structural diversification in natural product biosynthesis. |
| [46] |
Dang TT, Facchini PJ. 2012. Characterization of three O-methyltransferases involved in noscapine biosynthesis in opium poppy. |
| [47] |
Dang TT, Facchini PJ. 2014. Cloning and characterization of canadine synthase involved in noscapine biosynthesis in opium poppy. |
| [48] |
Okada N, Koizumi N, Tanaka T, Ohkubo H, Nakanishi S, Yamada Y. 1989. Isolation, sequence, and bacterial expression of a cDNA for (S)-tetrahydroberberine oxidase from cultured berberine-producing Coptis japonica cells. |
| [49] |
Tu TQ, Do PT, Van Nguyen D, Pham NTT, Nguyen TT, et al. 2022. The columbamine O-methyltransferase gene (CoOMT) is capable of increasing alkaloid content in transgenic tobacco plants. |
| [50] |
Takemura T, Ikezawa N, Iwasa K, Sato F. 2013. Molecular cloning and characterization of a cytochrome P450 in sanguinarine biosynthesis from Eschscholzia californica cells. |
| [51] |
Beaudoin GAW, Facchini PJ. 2014. Benzylisoquinoline alkaloid biosynthesis in opium poppy. |
| [52] |
Vadhel A, Bashir S, Mir AH, Girdhar M, Kumar D, et al. 2023. Opium alkaloids, biosynthesis, pharmacology and association with cancer occurrence. |
| [53] |
Pathak S, Lakhwani D, Gupta P, Mishra BK, Shukla S, et al. 2013. Comparative transcriptome analysis using high papaverine mutant of Papaver somniferum reveals pathway and uncharacterized steps of papaverine biosynthesis. |
| [54] |
Desgagné-Penix I, Facchini PJ. 2012. Systematic silencing of benzylisoquinoline alkaloid biosynthetic genes reveals the major route to papaverine in opium poppy. |
| [55] |
Ounaroon A, Decker G, Schmidt J, Lottspeich F, Kutchan TM. 2003. (R,S)-Reticuline 7-O-methyltransferase and (R,S)-norcoclaurine 6-O-methyltransferase of Papaver somniferum − cDNA cloning and characterization of methyl transfer enzymes of alkaloid biosynthesis in opium poppy. |
| [56] |
Hagel JM, Beaudoin GAW, Fossati E, Ekins A, Martin VJJ, et al. 2012. Characterization of a flavoprotein oxidase from opium poppy catalyzing the final steps in sanguinarine and papaverine biosynthesis. |
| [57] |
Liscombe DK, Facchini PJ. 2007. Molecular cloning and characterization of tetrahydroprotoberberine cis-N-methyltransferase, an enzyme involved in alkaloid biosynthesis in opium poppy. |
| [58] |
Beaudoin GAW, Facchini PJ. 2013. Isolation and characterization of a cDNA encoding (S)-cis-N-methylstylopine 14-hydroxylase from opium poppy, a key enzyme in sanguinarine biosynthesis. |
| [59] |
Hirata K, Poeaknapo C, Schmidt J, Zenk MH. 2004. 1, 2-Dehydroreticuline synthase, the branch point enzyme opening the morphinan biosynthetic pathway. |
| [60] |
De-Eknamkul W, Zenk MH. 1992. Purification and properties of 1, 2-dehydroreticuline reductase from Papaver somniferum seedlings. |
| [61] |
Higashi Y, Kutchan TM, Smith TJ. 2011. Atomic structure of salutaridine reductase from the opium poppy (Papaver somniferum). |
| [62] |
Gesell A, Rolf M, Ziegler J, Díaz Chávez ML, Huang FC, et al. 2009. CYP719B1 is salutaridine synthase, the C-C phenol-coupling enzyme of morphine biosynthesis in opium poppy. |
| [63] |
Grothe T, Lenz R, Kutchan TM. 2001. Molecular characterization of the salutaridinol 7-O-acetyltransferase involved in morphine biosynthesis in opium poppy Papaver somniferum. |
| [64] |
Carr SC, Torres MA, Morris JS, Facchini PJ, Ng KKS. 2021. Structural studies of codeinone reductase reveal novel insights into aldo-keto reductase function in benzylisoquinoline alkaloid biosynthesis. |
| [65] |
Singh W, Hui C, Li C, Huang M. 2021. Thebaine is selectively demethylated by thebaine 6-O-demethylase and codeine-3-O-demethylase at distinct binding sites: a computational study. |
| [66] |
Purwanto R, Hori K, Yamada Y, Sato F. 2017. Unraveling additional O-methylation steps in benzylisoquinoline alkaloid biosynthesis in California poppy (Eschscholzia californica). |
| [67] |
Jeyasri R, Muthuramalingam P, Karthick K, Shin H, Choi SH, et al. 2023. Methyl jasmonate and salicylic acid as powerful elicitors for enhancing the production of secondary metabolites in medicinal plants: an updated review. |
| [68] |
Pandey P, Tripathi A, Dwivedi S, Lal K, Jhang T. 2023. Deciphering the mechanisms, hormonal signaling, and potential applications of endophytic microbes to mediate stress tolerance in medicinal plants. |
| [69] |
Lala S. 2021. Nanoparticles as elicitors and harvesters of economically important secondary metabolites in higher plants: A review. |
| [70] |
De Geyter N, Gholami A, Goormachtig S, Goossens A. 2012. Transcriptional machineries in jasmonate-elicited plant secondary metabolism. |
| [71] |
Hara M, Morio K, Yazaki K, Tanaka S, Tabata M. 1995. Separation and characterization of cytokinin-inducible (S)-tetrahydroberberine oxidases controlling berberine biosynthesis in Thalictrum minus cell cultures. |
| [72] |
Hara M, Tanaka S, Tabata M. 1994. Induction of a specific methyltransferase activity regulating berberine biosynthesis by cytokinin in Thalictrum minus cell cultures. |
| [73] |
Kobayashi Y, Hara M, Fukui H, Tabata M. 1991. The role of ethylene in berberine production by Thalictrum minus cell suspension cultures. |
| [74] |
Roos W, Viehweger K, Dordschbal B, Schumann B, Evers S, et al. 2006. Intracellular pH signals in the induction of secondary pathways – The case of Eschscholzia californica. |
| [75] |
Heinze M, Steighardt J, Gesell A, Schwartze W, Roos W. 2007. Regulatory interaction of the Galpha protein with phospholipase A2 in the plasma membrane of Eschscholzia californica. |
| [76] |
Färber K, Schumann B, Miersch O, Roos W. 2003. Selective desensitization of jasmonate- and pH-dependent signaling in the induction of benzophenanthridine biosynthesis in cells of Eschscholzia californica. |
| [77] |
Facchini PJ, Johnson AG, Poupart J, de Luca V. 1996. Uncoupled defense gene expression and antimicrobial alkaloid accumulation in elicited opium poppy cell cultures. |
| [78] |
Pandey SS, Singh S, Vivek Babu CS, Shanker K, Srivastava NK, et al. 2016. Endophytes of opium poppy differentially modulate host plant productivity and genes for the biosynthetic pathway of benzylisoquinoline alkaloids. |
| [79] |
Ray T, Pandey SS, Pandey A, Srivastava M, Shanker K, et al. 2019. Endophytic consortium with diverse gene-regulating capabilities of benzylisoquinoline alkaloids biosynthetic pathway can enhance endogenous morphine biosynthesis in Papaver somniferum. |
| [80] |
Gurkok T, Turktas M, Parmaksiz I, Unver T. 2015. Transcriptome profiling of alkaloid biosynthesis in elicitor induced opium poppy. |
| [81] |
Jablonická V, Ziegler J, Vatehová Z, Lišková D, Heilmann I, et al. 2018. Inhibition of phospholipases influences the metabolism of wound-induced benzylisoquinoline alkaloids in Papaver somniferum L. |
| [82] |
Mishra S, Triptahi V, Singh S, Phukan UJ, Gupta MM, et al. 2013. Wound induced tanscriptional regulation of benzylisoquinoline pathway and characterization of wound inducible PsWRKY transcription factor from Papaver somniferum. |
| [83] |
Müller H, Heinze M, Heinke R, Schmidt J, Roos W. 2014. Self-regulation of phytoalexin production: a non-biosynthetic enzyme controls alkaloid biosynthesis in cultured cells of Eschscholzia californica. |
| [84] |
Heinze M, Brandt W, Marillonnet S, Roos W. 2015. "Self" and "non-self" in the control of phytoalexin biosynthesis: Plant phospholipases A2 with alkaloid-specific molecular fingerprints. |
| [85] |
Gundlach H, Müller MJ, Kutchan TM, Zenk MH. 1992. Jasmonic acid is a signal transducer in elicitor-induced plant cell cultures. |
| [86] |
Cho HY, Lee-Parsons CWT, Yoon SH, Rhee HS, Park JM. 2007. Enhanced benzophenanthridine alkaloid production and protein expression with combined elicitor in Eschscholtzia californica suspension cultures. |
| [87] |
Heinze M, Roos W. 2013. Assay of phospholipase A activity. |
| [88] |
Heinze M, Herre M, Massalski C, Hermann I, Conrad U, et al. 2013. Signal transfer in the plant plasma membrane: phospholipase A2 is regulated via an inhibitory Gα protein and a cyclophilin. |
| [89] |
Viehweger K, Dordschbal B, Roos W. 2002. Elicitor-activated phospholipase A2 generates lysophosphatidylcholines that mobilize the vacuolar H+ pool for pH signaling via the activation of Na+-dependent proton fluxes. |
| [90] |
Angelova S, Buchheim M, Frowitter D, Schierhorn A, Roos W. 2010. Overproduction of alkaloid phytoalexins in California poppy cells is associated with the co-expression of biosynthetic and stress-protective enzymes. |
| [91] |
Viehweger K, Schwartze W, Schumann B, Lein W, Roos W. 2006. The Galpha protein controls a pH-dependent signal path to the induction of phytoalexin biosynthesis in Eschscholzia californica. |
| [92] |
Schwartze W, Roos W. 2008. The signal molecule lysophosphatidylcholine in Eschscholzia californica is rapidly metabolized by reacylation. |
| [93] |
Roos W, Evers S, Hieke M, Tschope M, Schumann B. 1998. Shifts of intracellular pH distribution as a part of the signal mechanism leading to the elicitation of benzophenanthridine alkaloids. Phytoalexin biosynthesis in cultured cells of Eschscholtzia californica. |
| [94] |
Mariani ME, Fidelio GD. 2019. Secretory phospholipases A2 in plants. |
| [95] |
Jablonická V, Mansfeld J, Heilmann I, Obložinský M, Heilmann M. 2016. Identification of a secretory phospholipase A2 from Papaver somniferum L. that transforms membrane phospholipids. |
| [96] |
Sheikh AH, Eschen-Lippold L, Pecher P, Hoehenwarter W, Sinha AK, et al. 2016. Regulation of WRKY46 transcription factor function by mitogen-activated protein kinases in Arabidopsis thaliana. Frontiers in Plant Science 7:61 |
| [97] |
Ma N, Sun P, Li ZY, Zhang FJ, Wang XF, et al. 2024. Plant disease resistance outputs regulated by AP2/ERF transcription factor family. |
| [98] |
Yamada Y, Yoshimoto T, Yoshida ST, Sato F. 2016. Characterization of the promoter region of biosynthetic enzyme genes involved in berberine biosynthesis in Coptis japonica. |
| [99] |
Zhang M, Lu P, Zheng Y, Huang X, Liu J, et al. 2024. Genome-wide identification of AP2/ERF gene family in Coptis Chinensis Franch reveals its role in tissue-specific accumulation of benzylisoquinoline alkaloids. |
| [100] |
Yamada Y, Koyama T, Sato F. 2011. Basic helix-loop-helix transcription factors and regulation of alkaloid biosynthesis. |
| [101] |
Yamada Y, Motomura Y, Sato F. 2015. CjbHLH1 homologs regulate sanguinarine biosynthesis in Eschscholzia californica cells. Plant & Cell Physiology 56:1019−30 |
| [102] |
Goossens J, Mertens J, Goossens A. 2017. Role and functioning of bHLH transcription factors in jasmonate signalling. |
| [103] |
Yamada Y, Kokabu Y, Chaki K, Yoshimoto T, Ohgaki M, et al. 2011. Isoquinoline alkaloid biosynthesis is regulated by a unique bHLH-type transcription factor in Coptis japonica. |
| [104] |
Kato N, Dubouzet E, Kokabu Y, Yoshida S, Taniguchi Y, et al. 2007. Identification of a WRKY protein as a transcriptional regulator of benzylisoquinoline alkaloid biosynthesis in Coptis japonica. |
| [105] |
Yamada Y, Sato F. 2016. Tyrosine phosphorylation and protein degradation control the transcriptional activity of WRKY involved in benzylisoquinoline alkaloid biosynthesis. |
| [106] |
Yamada Y, Shimada T, Motomura Y, Sato F. 2017. Modulation of benzylisoquinoline alkaloid biosynthesis by heterologous expression of CjWRKY1 in Eschscholzia californica cells. |
| [107] |
Huang X, Jia A, Huang T, Wang L, Yang G, et al. 2023. Genomic profiling of WRKY transcription factors and functional analysis of CcWRKY7, CcWRKY29, and CcWRKY32 related to protoberberine alkaloids biosynthesis in Coptis chinensis Franch. |
| [108] |
Liu W, Tian X, Feng Y, Hu J, Wang B, et al. 2023. Genome-wide analysis of bHLH gene family in Coptis chinensis provides insights into the regulatory role in benzylisoquinoline alkaloid biosynthesis. |
| [109] |
Yamada Y, Nishida S, Shitan N, Sato F. 2020. Genome-wide identification of AP2/ERF transcription factor-encoding genes in California poppy (Eschscholzia californica) and their expression profiles in response to methyl jasmonate. |
| [110] |
Apuya NR, Park JH, Zhang L, Ahyow M, Davidow P, et al. 2008. Enhancement of alkaloid production in opium and California poppy by transactivation using heterologous regulatory factors. |
| [111] |
Mishra S, Phukan UJ, Tripathi V, Singh DK, Luqman S, et al. 2015. PsAP2 an AP2/ERF family transcription factor from Papaver somniferum enhances abiotic and biotic stress tolerance in transgenic tobacco. |
| [112] |
Hayashi S, Watanabe M, Kobayashi M, Tohge T, Hashimoto T, et al. 2020. Genetic manipulation of transcriptional regulators alters nicotine biosynthesis in tobacco. |
| [113] |
Paul P, Singh SK, Patra B, Sui X, Pattanaik S, et al. 2017. A differentially regulated AP2/ERF transcription factor gene cluster acts downstream of a MAP kinase cascade to modulate terpenoid indole alkaloid biosynthesis in Catharanthus roseus. |
| [114] |
van der Fits L, Memelink J. 2001. The jasmonate-inducible AP2/ERF-domain transcription factor ORCA3 activates gene expression via interaction with a jasmonate-responsive promoter element. |
| [115] |
Wang Y, Wang Y, Pan A, Miao Q, Han Y, et al. 2024. CaERF1-mediated ABA signal positively regulates camptothecin biosynthesis by activating the iridoid pathway in Camptotheca acuminata. |
| [116] |
Mizoi J, Shinozaki K, Yamaguchi-Shinozaki K. 2012. AP2/ERF family transcription factors in plant abiotic stress responses. |
| [117] |
Yokoyama R. 2024. Evolution of aromatic amino acid metabolism in plants: a key driving force behind plant chemical diversity in aromatic natural products. |
| [118] |
Yokoyama R, Kleven B, Gupta A, Wang Y, Maeda HA. 2022. 3-Deoxy-ᴅ-arabino-heptulosonate 7-phosphate synthase as the gatekeeper of plant aromatic natural product biosynthesis. |
| [119] |
Lopez-Nieves S, El-Azaz J, Men Y, Holland CK, Feng T, et al. 2022. Two independently evolved natural mutations additively deregulate TyrA enzymes and boost tyrosine production in planta. |
| [120] |
Tzin V, Malitsky S, Zvi MMB, Bedair M, Sumner L, et al. 2012. Expression of a bacterial feedback-insensitive 3-deoxy-ᴅ-arabino-heptulosonate 7-phosphate synthase of the shikimate pathway in Arabidopsis elucidates potential metabolic bottlenecks between primary and secondary metabolism. |
| [121] |
Yokoyama R, de Oliveira MVV, Kleven B, Maeda HA. 2021. The entry reaction of the plant shikimate pathway is subjected to highly complex metabolite-mediated regulation. |
| [122] |
Rippert P, Matringe M. 2002. Purification and kinetic analysis of the two recombinant arogenate dehydrogenase isoforms of Arabidopsis thaliana. |
| [123] |
Schenck CA, Maeda HA. 2018. Tyrosine biosynthesis, metabolism, and catabolism in plants. |
| [124] |
Schenck CA, Men Y, Maeda HA. 2017. Conserved molecular mechanism of TyrA dehydrogenase substrate specificity underlying alternative tyrosine biosynthetic pathways in plants and microbes. |
| [125] |
Yokoyama R, de Oliveira MVV, Takeda-Kimura Y, Ishihara H, Alseekh S, et al. 2022. Point mutations that boost aromatic amino acid production and CO2 assimilation in plants. |
| [126] |
El-Azaz J, Moore B, Takeda-Kimura Y, Yokoyama R, Wijesingha Ahchige M, et al. 2023. Coordinated regulation of the entry and exit steps of aromatic amino acid biosynthesis supports the dual lignin pathway in grasses. |
| [127] |
Mishra R, Joshi RK, Zhao K. 2020. Base editing in crops: current advances, limitations and future implications. |
| [128] |
Komor AC, Kim YB, Packer MS, Zuris JA, Liu DR. 2016. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. |
| [129] |
Matsoukas IG. 2018. Commentary: programmable base editing of A·T to G·C in genomic DNA without DNA cleavage. |
| [130] |
Anzalone AV, Randolph PB, Davis JR, Sousa AA, Koblan LW, et al. 2019. Search-and-replace genome editing without double-strand breaks or donor DNA. |
| [131] |
Nakagawa A, Minami H, Kim JS, Koyanagi T, Katayama T, et al. 2011. A bacterial platform for fermentative production of plant alkaloids. |
| [132] |
Nakagawa A, Nakamura S, Matsumura E, Yashima Y, Takao M, et al. 2021. Selection of the optimal tyrosine hydroxylation enzyme for (S)-reticuline production in Escherichia coli. |
| [133] |
Minami H, Kim JS, Ikezawa N, Takemura T, Katayama T, et al. 2008. Microbial production of plant benzylisoquinoline alkaloids. |
| [134] |
Nakagawa A, Matsumura E, Koyanagi T, Katayama T, Kawano N, et al. 2016. Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli. |
| [135] |
DeLoache WC, Russ ZN, Narcross L, Gonzales AM, Martin VJJ, et al. 2015. An enzyme-coupled biosensor enables (S)-reticuline production in yeast from glucose. |
| [136] |
Trenchard IJ, Siddiqui MS, Thodey K, Smolke CD. 2015. De novo production of the key branch point benzylisoquinoline alkaloid reticuline in yeast. |
| [137] |
Li Q, Jiao X, Li X, Shi W, Ma Y, et al. 2024. Identification of the cytochrome P450s responsible for the biosynthesis of two types of aporphine alkaloids and their de novo biosynthesis in yeast. |
| [138] |
Galanie S, Thodey K, Trenchard IJ, Filsinger Interrante M, Smolke CD. 2015. Complete biosynthesis of opioids in yeast. |
| [139] |
Thodey K, Galanie S, Smolke CD. 2014. A microbial biomanufacturing platform for natural and semisynthetic opioids. |
| [140] |
Fossati E, Narcross L, Ekins A, Falgueyret JP, Martin VJJ. 2015. Synthesis of morphinan alkaloids in Saccharomyces cerevisiae. |
| [141] |
Gou Y, Li D, Zhao M, Li M, Zhang J, et al. 2024. Intein-mediated temperature control for complete biosynthesis of sanguinarine and its halogenated derivatives in yeast. |
| [142] |
Liu T, Gou Y, Zhang B, Gao R, Dong C, et al. 2022. Construction of ajmalicine and sanguinarine de novo biosynthetic pathways using stable integration sites in yeast. |
| [143] |
Li Y, Li S, Thodey K, Trenchard I, Cravens A, Smolke CD. 2018. Complete biosynthesis of noscapine and halogenated alkaloids in yeast. |
| [144] |
Li Y, Smolke CD. 2016. Engineering biosynthesis of the anticancer alkaloid noscapine in yeast. |
| [145] |
Jamil OK, Cravens A, Payne JT, Kim CY, Smolke CD. 2022. Biosynthesis of tetrahydropapaverine and semisynthesis of papaverine in yeast. |
| [146] |
Sasaki K, Tsurumaru Y, Yazaki K. 2009. Prenylation of flavonoids by biotransformation of yeast expressing plant membrane-bound prenyltransferase SfN8DT-1. |
| [147] |
Ro DK, Ouellet M, Paradise EM, Burd H, Eng D, et al. 2008. Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid. |
| [148] |
Mishra G, Mohapatra SK, Rout GR. 2024. Plant membrane transporters function under abiotic stresses: a review. |
| [149] |
Dastmalchi M, Chang L, Chen R, Yu L, Chen X, et al. 2019. Purine permease-type benzylisoquinoline alkaloid transporters in opium poppy. |
| [150] |
Shitan N, Dalmas F, Dan K, Kato N, Ueda K, et al. 2013. Characterization of Coptis japonica CjABCB2, an ATP-binding cassette protein involved in alkaloid transport. |
| [151] |
Shitan N, Bazin I, Dan K, Obata K, Kigawa K, et al. 2003. Involvement of CjMDR1, a plant multidrug-resistance-type ATP-binding cassette protein, in alkaloid transport in Coptis japonica. |
| [152] |
Yamada Y, Urui M, Oki H, Inoue K, Matsui H, et al. 2021. Transport engineering for improving the production and secretion of valuable alkaloids in Escherichia coli. |
| [153] |
Yamada Y, Nakagawa A, Sato F, Minami H, Shitan N. 2022. Transport engineering using tobacco transporter NtJAT1 enhances alkaloid production in Escherichia coli. |
| [154] |
Tian Y, Kong L, Li Q, Wang Y, Wang Y, et al. 2024. Structural diversity, evolutionary origin, and metabolic engineering of plant specialized benzylisoquinoline alkaloids. |
| [155] |
Shitan N, Kiuchi F, Sato F, Yazaki K, Yoshimatsu K. 2005. Establishment of Rhizobium-mediated transformation of Coptis japonica and molecular analyses of transgenic plants. |
| [156] |
Lotz D, Imani J, Ehlers K, Becker A. 2022. Towards a genetic model organism: an efficient method for stable genetic transformation of Eschscholzia californica (Ranunculales). |
| [157] |
Facchini PJ, Loukanina N, Blanche V. 2008. Genetic transformation via somatic embryogenesis to establish herbicide-resistant opium poppy. |
| [158] |
Modrzejewski D, Hartung F, Lehnert H, Sprink T, Kohl C, et al. 2020. Which factors affect the occurrence of off-target effects caused by the use of CRISPR/Cas: A systematic review in plants. |
| [159] |
Boke H, Ozhuner E, Turktas M, Parmaksiz I, Ozcan S, et al. 2015. Regulation of the alkaloid biosynthesis by miRNA in opium poppy. |
| [160] |
Carr SC, Facchini PJ, Ng KKS. 2024. Structural analysis of a ligand-triggered intermolecular disulfide switch in a major latex protein from opium poppy. |