doi:10.48130/FR-2023-0011

[1]

Fang C, Fernie AR, Luo J. 2019. Exploring the diversity of plant metabolism. Trends in Plant Science 24:83−98

doi: 10.1016/j.tplants.2018.09.006

[2]

McGarvey DJ, Croteau R. 1995. Terpenoid metabolism. The Plant Cell 7:1015−26

doi: 10.1105/tpc.7.7.1015

[3]

Pichersky E, Raguso RA. 2018. Why do plants produce so many terpenoid compounds? New Phytologist 220:692−702

doi: 10.1111/nph.14178

[4]

Ni R, Wang P, Zhan P, Tian H, Li T. 2021. Effects of different frying temperatures on the aroma profiles of fried mountain pepper (Litsea cubeba (Lour. ) Pers. ) oils and characterization of their key odorants. Food Chemistry 357:129786

doi: 10.1016/j.foodchem.2021.129786

[5]

Wu Z, Li L, Liu H, Yan X, Ma Y, et al. 2021. AaMYB15, an R2R3-MYB TF in Artemisia annua, acts as a negative regulator of artemisinin biosynthesis. Plant Science 308:110920

doi: 10.1016/j.plantsci.2021.110920

[6]

Yuan Y, Ren S, Liu X, Su L, Wu Y, et al. 2022. SlWRKY35 positively regulates carotenoid biosynthesis by activating the MEP pathway in tomato fruit. New Phytologist 234:164−78

doi: 10.1111/nph.17977

[7]

Chen Y, Li Z, Zhao Y, Gao M, Wang J, et al. 2020. The Litsea genome and the evolution of the laurel family. Nature Communications 11:1675

doi: 10.1038/s41467-020-15493-5

[8]

Han X, Zhang J, Han S, Chong S, Meng G, et al. 2022. The chromosome-scale genome of Phoebe bournei reveals contrasting fates of terpene synthase (TPS)-a and TPS-b subfamilies. Plant Communications 3:100410

doi: 10.1016/j.xplc.2022.100410

[9]

Rodríguez-Concepción M, Boronat A. 2015. Breaking new ground in the regulation of the early steps of plant isoprenoid biosynthesis. Current Opinion in Plant Biology 25:17−22

doi: 10.1016/j.pbi.2015.04.001

[10]

Saladié M, Wright LP, Garcia-Mas J, Rodriguez-Concepcion M, Phillips MA. 2014. The 2-C-methylerythritol 4-phosphate pathway in melon is regulated by specialized isoforms for the first and last steps. Journal of Experimental Botany 65:5077−92

doi: 10.1093/jxb/eru275

[11]

Rodríguez-concepción M, Ahumada I, Diez-Juez E, Sauret-Güeto S, Lois LM, et al. 2001. 1-Deoxy-D-xylulose 5-phosphate reductoisomerase and plastid isoprenoid biosynthesis during tomato fruit ripening. The Plant Journal 27:213−22

doi: 10.1046/j.1365-313x.2001.01089.x

[12]

Carretero-Paulet L, Lipska A, Pérez-Gil J, Sangari FJ, Albert VA, et al. 2013. Evolutionary diversification and characterization of the eubacterial gene family encoding DXR type II, an alternative isoprenoid biosynthetic enzyme. BMC Evolutionary Biology 13:180

doi: 10.1186/1471-2148-13-180

[13]

Grolle S, Bringer-Meyer S, Sahm H. 2000. Isolation of the dxr gene of Zymomonas mobilis and characterization of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase. FEMS Microbiology Letters 191:131−37

doi: 10.1111/j.1574-6968.2000.tb09329.x

[14]

Takahashi S, Kuzuyama T, Watanabe H, Seto H. 1998. A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis. Proceedings of the National Academy of Sciences of the United States of America 95:9879−84

doi: 10.1073/pnas.95.17.9879

[15]

Sharma R, Devi K, Modi MK, Sen P. 2021. In silico characterization and differential expression analysis of 1-deoxy-d-xylulose-5-phosphate reductoisomerase (DXR) of Centella asiatica. 3 Biotech 11:184

doi: 10.1007/s13205-021-02723-w

[16]

Zhang Y, Yan H, Li Y, Xiong Y, Niu M, et al. 2021. Molecular cloning and functional analysis of 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Santalum album. Genes 12:626

doi: 10.3390/genes12050626

[17]

Zheng Q, Yu L, Liu Z, Li M, Xiang F, et al. 2004. [Cloning and analysis of cDNA encoding key enzyme gene (dxr) of the non-MVA pathway in Taxus chinensis cells]. Sheng Wu Gong Cheng Xue Bao 20:548−53

[18]

Zhou L, Yang G, Sun H, Tang J, Yang J, et al. 2017. Effects of different doses of cadmium on secondary metabolites and gene expression in Artemisia annua L. Frontiers of Medicine 11:137−46

doi: 10.1007/s11684-016-0486-3

[19]

Fung PK, Krushkal J, Weathers PJ. 2010. Computational analysis of the evolution of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, an important enzyme in plant terpene biosynthesis. Chemistry Biodiversity 7:1098−110

doi: 10.1002/cbdv.200900313

[20]

Chang K, Qiu F, Chen M, Zeng L, Liu X, et al. 2014. Engineering the MEP pathway enhanced ajmalicine biosynthesis. Biotechnology and Applied Biochemistry 61:249−55

doi: 10.1002/bab.1176

[21]

Ahmad B, Dar TA, Khan MMA, Ahmad A, Rinklebe J, et al. 2022. Oligochitosan fortifies antioxidative and photosynthetic metabolism and enhances secondary metabolite accumulation in arsenic-stressed peppermint. Frontiers in Plant Science 13:987746

doi: 10.3389/fpls.2022.987746

[22]

Hu Z, Tang B, Wu Q, Zheng J, Leng P, Zhang K. 2017. Transcriptome sequencing analysis reveals a difference in monoterpene biosynthesis between scented Lilium 'Siberia' and unscented Lilium 'novano'. Frontiers in Plant Science 8:1351

doi: 10.3389/fpls.2017.01351

[23]

Majdi M, Malekzadeh-Mashhady A, Maroufi A, Crocoll C. 2017. Tissue-specific gene-expression patterns of genes associated with thymol/carvacrol biosynthesis in thyme (Thymus vulgaris L.) and their differential changes upon treatment with abiotic elicitors. Plant Physiology and Biochemistry 115:152−62

doi: 10.1016/j.plaphy.2017.03.016

[24]

Xu C, Wei H, Movahedi A, Sun W, Ma X, et al. 2019. Evaluation, characterization, expression profiling, and functional analysis of DXS and DXR genes of Populus trichocarpa. Plant Physiology and Biochemistry 142:94−105

doi: 10.1016/j.plaphy.2019.05.034

[25]

Mendoza-Poudereux I, Muñoz-Bertomeu J, Arrillaga I, Segura J. 2014. Deoxyxylulose 5-phosphate reductoisomerase is not a rate-determining enzyme for essential oil production in spike lavender. Journal of Plant Physiology 171:1564−70

doi: 10.1016/j.jplph.2014.07.012

[26]

You MK, Lee YJ, Kim JK, Baek SA, Jeon YA, et al. 2020. The organ-specific differential roles of rice DXS and DXR, the first two enzymes of the MEP pathway, in carotenoid metabolism in Oryza sativa leaves and seeds. BMC Plant Biology 20:167

doi: 10.1186/s12870-020-02357-9

[27]

Prakash A, Vadivel V. 2020. Citral and linalool nanoemulsions: impact of synergism and ripening inhibitors on the stability and antibacterial activity against Listeria monocytogenes. Journal of Food Science and Technology 57:1495−504

doi: 10.1007/s13197-019-04185-8

[28]

Wang H, Li Y, Li Z, Ma R, Bai X, et al. 2022. Inhibition of Cronobacter sakazakii by Litsea cubeba essential oil and the antibacterial mechanism. Food 11:3900

doi: 10.3390/foods11233900

[29]

Borotová P, Galovičová L, Vukovic NL, Vukic M, Kunová S, et al. 2022. Role of Litsea cubeba essential oil in agricultural products safety: antioxidant and antimicrobial applications. Plants 11:1504

doi: 10.3390/plants11111504

[30]

Demetriou AA, Seifter E, Levenson SM. 1974. Effect of vitamin A and Citral on peritoneal adhesion formation. The Journal of Surgical Research 17:325−29

doi: 10.1016/0022-4804(74)90138-3

[31]

Quach NT, Nguyen QH, Vu THN, Le TTH, Ta TTT, et al. 2021. Plant-derived bioactive compounds produced by Streptomyces variabilis LCP18 associated with Litsea cubeba (Lour.) Pers as potential target to combat human pathogenic bacteria and human cancer cell lines. Brazilian Journal of Microbiology 52:1215−24

doi: 10.1007/s42770-021-00510-6

[32]

Dai J, Li C, Cui H, Lin L. 2021. Unraveling the anti-bacterial mechanism of Litsea cubeba essential oil against E. coli O157: H7 and its application in vegetable juices. International Journal of Food Microbiology 338:108989

doi: 10.1016/j.ijfoodmicro.2020.108989

[33]

Si L, Chen Y, Han X, Zhan Z, Tian S, et al. 2012. Chemical composition of essential oils of Litsea cubeba harvested from its distribution areas in China. Molecules 17:7057−66

doi: 10.3390/molecules17067057

[34]

Wang M, Gao M, Zhao Y, Chen Y, Wu L, et al. 2022. LcERF19, an AP2/ERF transcription factor from Litsea cubeba, positively regulates geranial and neral biosynthesis. Horticulture Research 9:uhac093

doi: 10.1093/hr/uhac093

[35]

Wang M, Jiao Y, Zhao Y, Gao M, Wu L, et al. 2022. Phytohormone and transcriptome of pericarp reveals jasmonate and LcMYC2 are involved in neral and geranial biosynthesis in Litsea cubeba. Industrial Crops and Products 177:114423

doi: 10.1016/j.indcrop.2021.114423

[36]

Wu L, Zhao Y, Zhang Q, Chen Y, Gao M, et al. 2020. Overexpression of the 3-hydroxy-3-methylglutaryl-CoA synthase gene LcHMGS effectively increases the yield of monoterpenes and sesquiterpenes. Tree Physiology 40:1095−107

doi: 10.1093/treephys/tpaa045

[37]

Zhao Y, Chen Y, Gao M, Yin H, Wu L, et al. 2020. Overexpression of geranyl diphosphate synthase small subunit 1 (LcGPPS. SSU1) enhances the monoterpene content and biomass. Industrial Crops and Products 143:111926

doi: 10.1016/j.indcrop.2019.111926

[38]

Lin L, Han X, Chen Y, Wu Q, Wang Y. 2013. Identification of appropriate reference genes for normalizing transcript expression by quantitative real-time PCR in Litsea cubeba. Molecular Genetics and Genomics 288:727−37

doi: 10.1007/s00438-013-0785-1

[39]

Schardl CL, Byrd AD, Benzion G, Altschuler MA, Hildebrand DF, et al. 1987. Design and construction of a versatile system for the expression of foreign genes in plants. Gene 61:1−11

doi: 10.1016/0378-1119(87)90359-3

[40]

Gao M, Lin L, Chen Y, Wang Y. 2016. Digital gene expression profiling to explore differentially expressed genes associated with terpenoid biosynthesis during fruit development in Litsea cubeba. Molecules 21:1251

doi: 10.3390/molecules21091251

[41]

Han X, Wang Y, Chen Y, Lin L, Wu Q. 2013. Transcriptome sequencing and expression analysis of terpenoid biosynthesis genes in Litsea cubeba. PLoS One 8:e76890

doi: 10.1371/journal.pone.0076890

[42]

Vaccaro M, Ocampo Bernal V, Malafronte N, De Tommasi N, Leone A. 2019. High yield of bioactive abietane diterpenes in Salvia sclarea hairy roots by overexpressing cyanobacterial DXS or DXR genes. Planta Medica 85:973−80

doi: 10.1055/a-0895-5878

[43]

Pateraki I, Kanellis AK. 2010. Stress and developmental responses of terpenoid biosynthetic genes in Cistus creticus subsp. creticus. Plant Cell Reports 29:629−41

doi: 10.1007/s00299-010-0849-1

[44]

Gupta P, Agarwal AV, Akhtar N, Sangwan RS, Singh SP, et al. 2013. Cloning and characterization of 2-C-methyl-D-erythritol-4-phosphate pathway genes for isoprenoid biosynthesis from Indian ginseng, Withania somnifera. Protoplasma 250:285−95

doi: 10.1007/s00709-012-0410-x

[45]

Han M, Heppel SC, Su T, Bogs J, Zu Y, et al. 2013. Enzyme inhibitor studies reveal complex control of methyl-D-erythritol 4-phosphate (MEP) pathway enzyme expression in Catharanthus roseus. PLoS One 8:e62467

doi: 10.1371/journal.pone.0062467

[46]

Liu B, Liu Q, Zhou Z, Yin H, Xie Y. 2022. Overexpression of geranyl diphosphate synthase (PmGPPS1) boosts monoterpene and diterpene production involved in the response to pine wood nematode invasion. Tree Physiology 42:411−24

doi: 10.1093/treephys/tpab103

[47]

Yin JL, Wong WS, Jang IC, Chua NH. 2017. Co-expression of peppermint geranyl diphosphate synthase small subunit enhances monoterpene production in transgenic tobacco plants. The New Phytologist 213:1133−44

doi: 10.1111/nph.14280

[48]

Burlat V, Oudin A, Courtois M, Rideau M, St-Pierre B. 2004. Co-expression of three MEP pathway genes and geraniol 10-hydroxylase in internal phloem parenchyma of Catharanthus roseus implicates multicellular translocation of intermediates during the biosynthesis of monoterpene indole alkaloids and isoprenoid-derived primary metabolites. The Plant Journal 38:131−41

doi: 10.1111/j.1365-313X.2004.02030.x

[49]

Miller B, Heuser T, Zimmer W. 2000. Functional involvement of a deoxy-D-xylulose 5-phosphate reductoisomerase gene harboring locus of Synechococcus leopoliensis in isoprenoid biosynthesis. FEBS Letters 481:221−26

doi: 10.1016/S0014-5793(00)02014-7

[50]

Zhang T, Sun M, Guo Y, Shi X, Yang Y, et al. 2018. Overexpression of LiDXS and LiDXR from lily (Lilium 'Siberia') enhances the terpenoid content in tobacco flowers. Frontiers in Plant Science 9:909

doi: 10.3389/fpls.2018.00909

[51]

Dong C, Qu G, Guo J, Wei F, Gao S, et al. 2022. Rational design of geranylgeranyl diphosphate synthase enhances carotenoid production and improves photosynthetic efficiency in Nicotiana tabacum. Science Bulletin 67:315−27

doi: 10.1016/j.scib.2021.07.003

[52]

Simpson K, Quiroz LF, Rodriguez-Concepción M, Stange CR. 2016. Differential contribution of the first two enzymes of the MEP pathway to the supply of metabolic precursors for carotenoid and chlorophyll biosynthesis in carrot (Daucus carota). Frontiers in Plant Science 7:1344

doi: 10.3389/fpls.2016.01344

[53]

Movahedi A, Wei H, Pucker B, Ghaderi-Zefrehei M, Rasouli F, et al. 2022. Isoprenoid biosynthesis regulation in poplars by methylerythritol phosphate and mevalonic acid pathways. Frontiers in Plant Science 13:968780

doi: 10.3389/fpls.2022.968780

[54]

Mendoza-Poudereux I, Kutzner E, Huber C, Segura J, Arrillaga I, et al. 2017. Dynamics of monoterpene formation in spike lavender plants. Metabolites 7:65

doi: 10.3390/metabo7040065

[55]

Mendoza-Poudereux I, Kutzner E, Huber C, Segura J, Eisenreich W, et al. 2015. Metabolic cross-talk between pathways of terpenoid backbone biosynthesis in spike lavender. Plant Physiology and Biochemistry 95:113−20

doi: 10.1016/j.plaphy.2015.07.029

[56]

Liao P, Chen X, Wang M, Bach TJ, Chye ML. 2018. Improved fruit α-tocopherol, carotenoid, squalene and phytosterol contents through manipulation of Brassica juncea 3-HYDROXY-3-METHYLGLUTARYL-COA SYNTHASE1 in transgenic tomato. Plant Biotechnology Journal 16:784−96

doi: 10.1111/pbi.12828

[57]

Pokhilko A, Bou-Torrent J, Pulido P, Rodríguez-Concepción M, Ebenhöh O. 2015. Mathematical modelling of the diurnal regulation of the MEP pathway in Arabidopsis. New Phytologist 206:1075−85

doi: 10.1111/nph.13258

[58]

Paetzold H, Garms S, Bartram S, Wieczorek J, Urós-Gracia EM, et al. 2010. The isogene 1-deoxy-D-xylulose 5-phosphate synthase 2 controls isoprenoid profiles, precursor pathway allocation, and density of tomato trichomes. Molecular Plant 3:904−16

doi: 10.1093/mp/ssq032