doi:10.48130/fmr-0023-0034

[1]

Jones PJ, Jew S. 2007. Functional food development: concept to reality. Trends in Food Science and Technology 18(7):387−90

doi: 10.1016/j.jpgs.2007.03.008

[2]

Akın S, Bölük C. 2020. Prevalence of comorbidities in patients with type–2 diabetes mellitus. Primary Care Diabetes. 14(5):431−34

doi: 10.1016/j.pcd.2019.12.006

[3]

Ekoru K, Doumatey A, Bentley AR, Chen G, Zhou J, et al. 2019. Type 2 diabetes complications and comorbidity in Sub-Saharan Africans. eClinical Medicine 16:30−41

doi: 10.1016/j.eclinm.2019.09.001

[4]

Ahmad AMRahmawati R,. 2022. Comorbidities and quality of life in people with stage 2 hypertension: A study in Yogyakarta, Indonesia. Proceedings of the Global Public Health Conference 5(1):8−16

doi: 10.17501/26138417.2022.5102

[5]

Olusanya AM, Olopade OB, Odeniyi IA, Fasanmade OA. 2021. Patterns of drug use among type 2 diabetic patients with comorbidities attending a tertiary centre in Lagos, Nigeria. Clinical Diabetology 10(4):342−48

doi: 10.5603/dk.a2021.0043

[6]

Iglay K, Hannachi H, Joseph Howie P, Xu J, Li X, et al. 2016. Prevalence and co-prevalence of comorbidities among patients with type 2 diabetes mellitus. Current Medical Research and Opinion 32(7):1243−52

doi: 10.1185/03007995.2016.1168291

[7]

Ademosun AO, Oboh G, Olasehinde TA, Adeoyo OO. 2018. From folk medicine to functional food: a review on the bioactive components and pharmacological properties of citrus peels. Oriental Pharmacology and Experimental Medicine 18:9−20

doi: 10.1007/s13596-017-0292-8

[8]

Ademosun AO. 2022. Citrus peels odyssey: From the waste bin to the lab bench to the dining table. Applied Food Research 2(1):100083

doi: 10.1016/j.afres.2022.100083

[9]

Brown L, Poudyal H, Panchal SK. 2015. Functional foods as potential therapeutic options for metabolic syndrome. Obesity Reviews 16(11):914−941

doi: 10.1111/obr.12313

[10]

Konstantinidi M, Koutelidakis AE. 2019. Functional foods and bioactive compounds: A review of its possible role on weight management and obesity's metabolic consequences. Medicines 6(3):94

doi: 10.3390/medicines6030094

[11]

Adebayo AA, Oboh G, Ademosun AO. 2019. Almond-supplemented diet improves sexual functions beyond Phosphodiesterase-5 inhibition in diabetic male rats. Heliyon 5(12):E03035

doi: 10.1016/j.heliyon.2019.e03035

[12]

Oboh G, Babatola LJ, Ademiluyi AO. 2018. In vitro inhibitory effects of mistletoes (Loranthus begwensis L.) phenolic-rich extracts on a-amylase, α-glucosidase, and angiotensin converting enzyme activities. Journal of Food Biochemistry 42:e12504

doi: 10.1111/jfbc.12504

[13]

Argano C, Natoli G, Mularo S, Nobili A, Monaco ML, Mannucci PM, Perticone F, Pietrangelo A, Corrao S. 2022. Impact of diabetes mellitus and its comorbidities on elderly patients hospitalized in internal medicine wards: Data from the RePoSi Registry. Healthcare 10(1):86

doi: 10.3390/healthcare10010086

[14]

Kashif RR, D'Cunha NM, Mellor DD, Alexopoulos NI, Sergi D, et al. 2022. Prickly pear cacti (Opuntia spp.) cladodes as a functional ingredient for hyperglycemia management: A brief narrative review. Medicinal 58(2):300

doi: 10.3390/medicina58020300

[15]

Viigimaa M, Vlachopoulos C, Lazaridis A, Doumas M. 2014. Management of erectile dysfunction in hypertension: Tips and tricks. World Journal of Cardiology 6(9):908−15

doi: 10.4330/wjc.v6.i9.908

[16]

Atlante A, Amadoro G, Bobba A, Latina V. 2020. Functional Foods: An Approach to Modulate Molecular Mechanisms of Alzheimer's Disease. Cells 9(11):2347

doi: 10.3390/cells9112347

[17]

Ademosun AO, Odanye OS, Oboh G. 2021. Orange peel flavored unripe plantain noodles with low glycemic index improved antioxidant status and reduced blood glucose levels in diabetic rats. Journal of Food Measurement and Characterization 15:3742−51

doi: 10.1007/s11694-021-00953-3

[18]

Küster-Boluda I, Vidal-Capilla I. 2017. Consumer attitudes in the election of functional foods. Spanish Journal of Marketing - ESIC 21(1):65−79

doi: 10.1016/j.sjme.2017.05.002

[19]

Long AN, Dagogo-Jack S. 2011. Comorbidities of diabetes and hypertension: mechanisms and approach to target organ protection. Journal of Clinical Hypertension 13(4):244−51

doi: 10.1111/j.1751-7176.2011.00434.x

[20]

Oboh G, Ademosun AO, Odubanjo OV, Akinbola IA. 2013. Antioxidative properties and inhibition of key enzymes relevant to type-2 diabetes and hypertension by essential oils from black pepper. Advances in Pharmacological and Pharmaceutical Sciences 2013:926047

doi: 10.1155/2013/926047

[21]

Nowakowska M, Zghebi SS, Ashcroft DM, Buchan I, chew-graham C, et al. 2019. The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort. BioMed Central 17(145

doi: 10.1186/s12916-019-1373-y

[22]

Sun NN, Wu TY Chau CF. 2016. Natural dietary and herbal products in anti-obesity treatment. Molecules 21(10):1351

doi: 10.3390/molecules21101351

[23]

Jha PN, Kusum V. 2020. Observational study to evaluate prevalence of comorbidities in Indian type 2 diabetes patients and its association with glycemic control at a tertiary care teaching hospital at Patna. International Journal of Research and Review. 7(10):185−89

[24]

Owonaro AP, Joshua EF, Daughter OAE, Nelson EC. 2017. Co-morbidities of patients with hypertension admitted to Amassoma General Hospital, Bayelsa State South-South of Nigeria. Global Journal of Pharmacy and Pharmaceutical Sciences 2(4):555594

doi: 10.19080/GJPPS.2017.02.555594

[25]

Ajeigbe OF, Ademosun AO, Oboh G. 2021. Relieving the tension in hypertension: Food–drug interactions and anti-hypertensive mechanisms of food bioactive compounds. Journal of Food Biochemistry 45:e13317

doi: 10.1111/jfbc.13317

[26]

Ajeigbe OF, Oboh G, Ademosun AO. 2021. Ficus plants in the co-management of hypertension and erectile dysfunction. Phytomedicine Plus 1(3):100096

doi: 10.1016/j.phyplu.2021.100096

[27]

Alkhatib A, Tsang C, Tiss A, Bahorun T, Arefanian H, et al. 2017. Functional Foods and Lifestyle Approaches for Diabetes Prevention and Management. Nutrients 9(12):1310

doi: 10.3390/nu9121310

[28]

Oboh G, Ademiluyi AO, Agunloye OM, Ademosun AO, Ogunsakin BG. 2019. Inhibitory effect of garlic, purple onion, and white onion on key enzymes linked with type 2 diabetes and hypertension. Journal of Dietary Supplements 16(1):105−18

doi: 10.1080/19390211.2018.1438553

[29]

Sirtori CR, Galli C, Anderson JW, Arnoldi A. 2009. Nutritional and nutraceutical approaches to dyslipidemia and atherosclerosis prevention: Focus on dietary proteins. Atherosclerosis 203(1):8−17

doi: 10.1016/j.atherosclerosis.2008.06.019

[30]

Mohamed S. 2014. Functional foods against metabolic syndrome (obesity diabetes, hypertension and dyslipidemia) and cardiovascular disease. Trends in Food Science and Technology 35(2):114−28

doi: 10.1016/j.jpgs.2013.11.001

[31]

Ademosun AO, Oboh G, Ajeigbe OF. 2021. Antioxidant activities and glycemic indices of ice creams enriched with orange (Citrus sinensis) and shaddock (Citrus maxima) peels and effects on rat lipid profiles. Journal of Food Biochemistry 45(7):e13813

doi: 10.1111/jfbc.13813

[32]

Duarte G, Barbosa LO, Rosa MEA. 2012. The management of psoriasis through diet. Psoriasis 2:45−53

doi: 10.2147/PTT.S24755

[33]

Venkatakrishnan K, Chiu HF, Wang CK. 2019. Extensive review of popular functional foods and nutraceuticals against obesity and its related complications with a special focus on randomized clinical trials. Food and Function 10(5):2313−29

doi: 10.1039/c9fo00293f

[34]

Leitolis A, Crestani S, Linder ÁE, da Silva-Santos JE. 2019. High-salt intake reduces apomorphine-induced penile erection and increases neurally mediated contractile responses of the cavernosal smooth muscle in rats. American Journal of Hypertension 32(12):1206−13

doi: 10.1093/ajh/hpz142

[35]

Kishimoto T, Kataoka T, Yamamoto Y, Asano G, Fukamoto A, et al. 2020. High salt intake impairs erectile function in salt-sensitive rats through mineralocorticoid receptor pathway beyond its effect on blood pressure. Journal of Sex Medicine. 17(7):1280−87

doi: 10.1016/j.jsxm.2020.04.384

[36]

Grillo A, Salvi L, Coruzzi P, Salvi P, Parati G. 2019. Sodium Intake and Hypertension. Nutrients. 11(9):1970

doi: 10.3390/nu11091970

[37]

Houston MC. 2011. The importance of potassium in managing hypertension. Current Hypertension Reports 13(4):309−17

doi: 10.1007/s11906-011-0197-8

[38]

Ajeigbe OF, Oboh G, Ademosun AO, Oyagbemi AA. 2021. Ficus asperifolia Miq-enriched biscuit diet protects against L-NAME induced hyperlipidemia and hypertension in rats. Food Frontiers 3(1):150−60

doi: 10.1002/fft2.101

[39]

Marrelli M, Amodeo V, Statti G, Conforti F. 2018. Biological Properties and Bioactive Components of Allium cepa L.: Focus on Potential Benefits in the Treatment of Obesity and Related Comorbidities. Molecules 24(1):119

doi: 10.3390/molecules24010119

[40]

Shi M, Loftus H, Mcainch AJ, Su XQ. 2017. Blueberry as a source of bioactive compounds for the treatment of obesity, type 2 diabetes and chronic inflammation. Journal of Functional Foods 30:16−29

doi: 10.1016/j.jff.2016.12.036

[41]

Ademosun AO, Oboh G, Adebayo AA, Olasehinde TA, Fasakin OW. 2022. Grapefruit peel extract mitigates paroxetine-induced erectile dysfunction in rats through stimulation of erectile response, antioxidant status, and inhibition of key enzymes related with impaired penile erection. Journal of Food Biochemistry 46(11):e14193

doi: 10.1111/jfbc.14193

[42]

Oboh G, Ademosun AO. 2011b. Phenolic extracts from grapefruit peels (Citrus Paradisi) inhibit key enzymes linked with type 2 diabetes and hypertension. Journal of Food Biochemistry 35(6):1703−1709

doi: 10.1111/J.1745-4514.2010.00495.x

[43]

Oboh G, Olasehinde TA, Ademosun AO. 2017a. Inhibition of enzymes linked to type-2 diabetes and hypertension by essential oils from peels of orange and lemon. International Journal of Food Properties 20(1):S586−S594

doi: 10.1080/10942912.2017.1303709

[44]

Cam M, Basyigit B, Alasalvar H, Yilmaztekin M, Ahhmed A, et al. 2020. Bioactive properties of powdered peppermint and spearmint extracts: Inhibition of key enzymes linked to hypertension and type 2 diabetes. Food Bioscience 35:100577

doi: 10.1016/j.fbio.2020.100577

[45]

Oyeleye SI, Adebayo AA, Ogunsuyi OB, Dada FA, Oboh G. 2017. Phenolic profile and Enzyme Inhibitory activities of Almond (Terminalia catappa) leaf and Stem bark. International Journal of Food Properties 20(3):2810−21

doi: 10.1080/10942912.2017.1375945

[46]

Oboh G, Ademiluyi AO, Ademosun AO, Olasehinde TA, Oyeleye SI, et al. 2015. Phenolic extract from Moringa oleifera leaves inhibits key enzymes linked to erectile dysfunction and oxidative stress in rats' penile tissues. Biochemistry Research International 5:175950

doi: 10.1155/2015/175950

[47]

Ademosun AO, Adebayo AA, Oboh G. 2019. Orange peels modulate antioxidant markers and key enzymes relevant to erection in the penile tissue of paroxetine-treated rats. Andrologia 51(9):e13371

doi: 10.1111/and.13371

[48]

Oboh G, Adebayo AA, Ademosun AO. 2017. Erection-stimulating, anti-diabetic and antioxidant properties of Hunteria umbellata and Cylicodiscus gabunensis water extractable phytochemicals. Journal of Complementary and Integrative Medicine 15(1):20160164

doi: 10.1515/jcim-2016-0164

[49]

Oyeleye SI, Olasehinde TA, Odumosu IP, Oboh G. 2022. Plantain peels restore sexual performance, hormonal imbalance, and modulate nitric oxide production and key enzymes of penile function in paroxetine-sexually impaired male rats. Journal of Food Biochemistry 46(11):e14261

doi: 10.1111/jfbc.14261

[50]

Sapkota B, Devkota HP, Poudel P. 2022. Citrus maxima (Brum.) Merr. (Rutaceae): Bioactive chemical constituents and pharmacological activities. Evidence-Based Complementary and Alternative Medicine 2022:8741669

doi: 10.1155/2022/8741669

[51]

Oboh G, Ademosun AO. 2011a. Shaddock peels (Citrus maxima) phenolic extracts inhibit α-amylase, α-glucosidase and angiotensin I-converting enzyme activities: a nutraceutical approach to diabetes management. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 5(3):148−52

doi: 10.1016/j.dsx.2012.02.008

[52]

Hursel R, Westerterp-Plantenga MS. 2013. Catechin-and caffeine-rich teas for control of body weight in humans. The American Journal of Clinical Nutrition 98(6):1682S−1693S

doi: 10.3945/ajcn.113.058396

[53]

Sartorius T, Peter A, Schulz N, Drescher A, Bergheim I, et al. 2014. Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity. PLoS ONE 9(3):e92358

doi: 10.1371/journal.pone.0092358

[54]

Yan F, Zheng X. 2017. Anthocyanin-rich mulberry fruit improves insulin resistance and protects hepatocytes against oxidative stress during hyperglycemia by regulating AMPK/ACC/mTOR pathway. Journal of Functional Foods 30:270−81

doi: 10.1016/j.jff.2017.01.027

[55]

He HJ, Wang GY, Gao Y, Ling WH, Yu ZW, et al. 2012. Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice. World Journal of Diabetes 3(5):94−104

doi: 10.4239/wjd.v3.i5.94

[56]

Akerele GP, Adedayo BC, Oboh G, Ademosun AO, Oyeleye SI. 2022. Glycemic indices and effect of bitter leaf (Vernonia amygdalina) flavored non-alcoholic wheat beer (NAWB) on key carbohydrate metabolizing enzymes in high fat diet fed (HFD)/STZ-induced diabetic Wistar rats. Journal of Food Biochemistry 46(12):e14511