[1]

Editorial Committee of Flora of China. 2004. Flora of China. Beijing, China: Science Press.

[2]

Pharmacopoeia Commission of the People's Republic of China. 2020. Pharmacopoeia of the People's Republic of China, Part I. Beijing, China: China Pharmaceutical Science and Technology Press. pp. 32, 230.

[3]

Fang L, Liao X, Zhang Q, Shi L, Zhou L, et al. 2021. An orthogonal experimental design and QuEChERS based UFLC-MS/MS for multi-pesticides and human exposure risk assessment in honeysuckle. Industrial Crops and Products 164:113384

doi: 10.1016/j.indcrop.2021.113384
[4]

Xiao O, Li M, Chen D, Chen J, Simal-Gandara J, et al. 2022. The dissipation, processing factors, metabolites, and risk assessment of pesticides in honeysuckle from field to table. Journal of Hazardous Materials 431:128519

doi: 10.1016/j.jhazmat.2022.128519
[5]

Zhou Z, Li X, Liu J, Dong L, Chen Q, et al. 2015. Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses. Cell Research 25(1):39−49

doi: 10.1038/cr.2014.130
[6]

Li X, Huang Y, Sun M, Ji H, Dou H, et al. 2018. Honeysuckle-encoded microRNA2911 inhibits enterovirus 71 replication via targeting VP1 gene. Antiviral Research 152:117−23

doi: 10.1016/j.antiviral.2018.02.015
[7]

Zhou LK, Zhou Z, Jiang XM, Zheng Y, Chen X, et al. 2020. Absorbed plant MIR2911 in honeysuckle decoction inhibits SARS-CoV-2 replication and accelerates the negative conversion of infected patients. Cell Discovery 6(1):54

doi: 10.1038/s41421-020-00197-3
[8]

Wang J, Zhou B, Hu X, Dong S, Hong M, et al. 2021. Deciphering the formulation secret underlying chinese Huo-clearing herbal drink. Frontiers in pharmacology 12:654699

doi: 10.3389/fphar.2021.654699
[9]

Cheng Z, Bao Y, Li Z, Wang J, Wang M, et al. 2023. Lonicera caerulea (Haskap berries): a review of development traceability, functional value, product development status, future opportunities, and challenges. Critical Reviews in Food Science and Nutrition 18:1−25

doi: 10.1080/10408398.2022.2061910
[10]

Hwang SJ, Kim YW, Park Y, Lee HJ, Kim KW. 2014. Anti-inflammatory effects of chlorogenic acid in lipopolysaccharide-stimulated RAW 264.7 cells. Inflammation Research 63:81−90

doi: 10.1007/s00011-013-0674-4
[11]

Ding Y, Cao Z, Cao L, Ding G, Wang Z, et al. 2017. Antiviral activity of chlorogenic acid against influenza A (H1N1/H3N2) virus and its inhibition of neuraminidase. Scientific Reports 7:45723

doi: 10.1038/srep45723
[12]

Shi H, Shi A, Dong L, Lu X, Wang Y, et al. 2016. Chlorogenic acid protects against liver fibrosis in vivo and in vitro through inhibition of oxidative stress. Clinical Nutrition 35(6):1366−73

doi: 10.1016/j.clnu.2016.03.002
[13]

Huang S, Wang LL, Xue NN, Li C, Guo HH, et al. 2019. Chlorogenic acid effectively treats cancers through induction of cancer cell differentiation. Theranostics 9(23):6745−63

doi: 10.7150/thno.34674
[14]

Wang J, Zhao XZ, Qi Q, Tao L, Zhao Q, et al. 2009. Macranthoside B, a hederagenin saponin extracted from Lonicera macranthoides and its anti-tumor activities in vitro and in vivo. Food and chemical toxicology 47(7):1716−21

doi: 10.1016/j.fct.2009.04.034
[15]

Kim GJ, Song DH, Yoo HS, Chung KH, Lee KJ, et al. 2017. Hederagenin supplementation alleviates the pro-inflammatory and apoptotic response to alcohol in rats. Nutrients 9(1):41

doi: 10.3390/nu9010041
[16]

Xie ZS, Zhao JP, Wu LM, Chu S, Cui ZH, et al. 2023. Hederagenin improves Alzheimer's disease through PPARα/TFEB-mediated autophagy. Phytomedicine 112:154711

doi: 10.1016/j.phymed.2023.154711
[17]

Chen J, Song Y, Li P. 2007. Capillary high-performance liquid chromatography with mass spectrometry for simultaneous determination of major flavonoids, iridoid glucosides and saponins in Flos Lonicerae. Journal of Chromatography A 1157(1-2):217−26

doi: 10.1016/j.chroma.2007.05.063
[18]

Chen Z, Tang N, You Y, Lan J, Liu Y, et al. 2015. Transcriptome analysis reveals the mechanism underlying the production of a high quantity of chlorogenic acid in young leaves of Lonicera macranthoides Hand.-Mazz. PLoS One 10(9):e0137212

doi: 10.1371/journal.pone.0137212
[19]

Yao XH, Xu JY, Hao JY, Wan Y, Chen T, et al. 2018. Microwave assisted extraction for the determination of chlorogenic acid in Flos Lonicerae by direct analysis in real time mass spectrometry (DART-MS). Journal of Chromatography B 1092:82−87

doi: 10.1016/j.jchromb.2018.05.045
[20]

Cai Z, Liao H, Wang C, Chen J, Tan M, et al. 2020. A comprehensive study of the aerial parts of Lonicera japonica Thunb. based on metabolite profiling coupled with PLS-DA. Phytochemical Analysis 31(6):786−800

doi: 10.1002/pca.2943
[21]

Wang L, Jiang Q, Hu J, Zhang Y, Li J. 2016. Research progress on chemical constituents of Lonicerae japonicae flos. BioMed Research International 2016:8968940

doi: 10.1155/2016/8968940
[22]

Fang Z, Li J, Yang R, Fang L, Zhang Y. 2020. A review: the triterpenoid saponins and biological activities of Lonicera Linn. Molecules 25(17):3773

doi: 10.3390/molecules25173773
[23]

Ge L, Xie Q, Jiang Y, Xiao L, Wan H, et al. 2022. Genus Lonicera: new drug discovery from traditional usage to modern chemical and pharmacological research. Phytomedicine 96:153889

doi: 10.1016/j.phymed.2021.153889
[24]

Wu HZ, Luo J, Yin YX, Wei Q. 2004. Effects of chlorogenic acid, an active compound activating calcineurin, purified from Flos Lonicerae on macrophage. Acta Pharmacologica Sinica 25(12):1685−89

[25]

Zhang X, Tong J, Zhou Y, Xu X. 2014. Research progress on pharmacodynamic components and pharmacological effects of honeysuckle. Chinese Pharmacological Bulletin 30(8):1049−54(in Chinese)

doi: 10.3969/j.issn.1001-1978.2014.08.004
[26]

Jeong SH, Park MY, Bhosale PB, Abusaliya A, Won CK, et al. 2023. Potential antioxidant and anti-inflammatory effects of Lonicera japonica and Citri Reticulatae Pericarpium polyphenolic extract (LCPE). Antioxidants 12(8):1582

doi: 10.3390/antiox12081582
[27]

Wang YD, He Y, Dai Z, Kang S, Zhang J, et al. 2016. A comparative study on bioactive constituents in different parts of Lonicera japonica determined by HPLC-ESI-MS(n). Journal of Asian Natural Products Research 18(10):988−1003

doi: 10.1080/10286020.2016.1205039
[28]

Gao W, Wang R, Li D, Liu K, Chen J, et al. 2016. Comparison of five Lonicera flowers by simultaneous determination of multi-components with single reference standard method and principal component analysis. Journal of Pharmaceutical and Biomedical Analysis 117:345−51

doi: 10.1016/j.jpba.2015.09.008
[29]

Vogt T. 2010. Phenylpropanoid biosynthesis. Molecular Plant 3(1):2−20

doi: 10.1093/mp/ssp106
[30]

Koukol J, Conn EE. 1961. The metabolism of aromatic compounds in higher plants. IV. Purification and properties of the phenylalanine deaminase of Hordeum vulgare. Journal of Biological Chemistry 236:2692−98

doi: 10.1016/S0021-9258(19)61721-7
[31]

Russell DW. 1971. The metabolism of aromatic compounds in higher plants. X. Properties of the cinnamic acid 4-hydroxylase of pea seedlings and some aspects of its metabolic and developmental control. Journal of Biological Chemistry 246:3870−78

doi: 10.1016/S0021-9258(18)62115-5
[32]

Hu Y, Gai Y, Yin L, Wang X, Feng C, et al. 2010. Crystal structures of a Populus tomentosa 4-coumarate: CoA ligase shed light on its enzymatic mechanisms. The Plant Cell 22(9):3093−104

doi: 10.1105/tpc.109.072652
[33]

Kong D, Li Y, Bai M, He H, Liang G, et al. 2017. Correlation between the dynamic accumulation of the main effective components and their associated regulatory enzyme activities at different growth stages in Lonicera japonica Thunb. Industrial Crops and Products 96:16−22

doi: 10.1016/j.indcrop.2016.11.024
[34]

Hoffmann L, Maury S, Martz F, Geoffroy P, Legrand M. 2003. Purification, cloning, and properties of an acyltransferase controlling shikimate and quinate ester intermediates in phenylpropanoid metabolism. Journal of Biological Chemistry 278(1):95−103

doi: 10.1074/jbc.M209362200
[35]

Peng X, Li W, Wang W, Bai G. 2010. Cloning and characterization of a cDNA coding a hydroxycinnamoyl-CoA quinate hydroxycinnamoyl transferase involved in chlorogenic acid biosynthesis in Lonicera japonica. Planta Medica 76(16):1921−26

doi: 10.1055/s-0030-1250020
[36]

Pu G, Wang P, Zhou B, Liu Z, Xiang F. 2013. Cloning and characterization of Lonicera japonica p-coumaroyl ester 3-hydroxylase which is involved in the biosynthesis of chlorogenic acid. Bioscience, Biotechnology & Biochemistry 77(7):1403−9

doi: 10.1271/bbb.130011
[37]

Li R, Xu J, Qi Z, Zhao S, Zhao R, et al. 2023. High-resolution genome mapping and functional dissection of chlorogenic acid production in Lonicera maackii. Plant Physiology 192(4):2902−22

doi: 10.1093/plphys/kiad295
[38]

Niggeweg R, Michael AJ, Martin C. 2004. Engineering plants with increased levels of the antioxidant chlorogenic acid. Nature biotechnology 22(6):746−54

doi: 10.1038/nbt966
[39]

Zhang J, Wu M, Li W, Bai G. 2017. Regulation of chlorogenic acid biosynthesis by hydroxycinnamoyl CoA quinate hydroxycinnamoyl transferase in Lonicera japonica. Plant Physiology and Biochemistry 121:74−79

doi: 10.1016/j.plaphy.2017.10.017
[40]

Villegas RJ, Kojima M. 1986. Purification and characterization of hydroxycinnamoyl D-glucose. Quinate hydroxycinnamoyl transferase in the root of sweet potato, Ipomoea batatas Lam. Journal of Biological Chemistry 261(19):8729−33

doi: 10.1016/S0021-9258(19)84441-1
[41]

Tanaka M, Kojima M. 1991. Purification and characterization of p-coumaroyl-D-glucose hydroxylase of sweet potato (Ipomoea batatas) roots. Archives of Biochemistry and Biophysics 284(1):151−57

doi: 10.1016/0003-9861(91)90277-p
[42]

Chang J, Luo J, He G. 2009. Regulation of polyphenols accumulation by combined overexpression/silencing key enzymes of phyenylpropanoid pathway. Acta Biochimica et Biophysica Sinica 41(2):123−30

doi: 10.1093/abbs/gmn014
[43]

Payyavula RS, Shakya R, Sengoda VG, Munyaneza JE, Swamy P, et al. 2015. Synthesis and regulation of chlorogenic acid in potato: Rerouting phenylpropanoid flux in HQT-silenced lines. Plant Biotechnology Journal 13(4):551−64

doi: 10.1111/pbi.12280
[44]

Li Y, Kong D, Bai M, He H, Wang H, et al. 2019. Correlation of the temporal and spatial expression patterns of HQT with the biosynthesis and accumulation of chlorogenic acid in Lonicera japonica flowers. Horticulture Research 6:73

doi: 10.1038/s41438-019-0154-2
[45]

Yuan Y, Wang Z, Jiang C, Wang X, Huang L. 2014. Exploiting genes and functional diversity of chlorogenic acid and luteolin biosyntheses in Lonicera japonica and their substitutes. Gene 534(2):408−16

doi: 10.1016/j.gene.2012.09.051
[46]

Tang N, Cao Z, Yang C, Ran D, Wu P, et al. 2021. A R2R3-MYB transcriptional activator LmMYB15 regulates chlorogenic acid biosynthesis and phenylpropanoid metabolism in Lonicera macranthoides. Plant Science 308:110924

doi: 10.1016/j.plantsci.2021.110924
[47]

Zha L, Liu S, Liu J, Jiang C, Yu S, et al. 2017. DNA methylation influences chlorogenic acid biosynthesis in Lonicera japonica by mediating LjbZIP8 to regulate phenylalanine ammonia-lyase 2 expression. Frontiers in Plant Science 8:1178

doi: 10.3389/fpls.2017.01178
[48]

Yan K, Zhao S, Bian L, Chen X. 2017. Saline stress enhanced accumulation of leaf phenolics in honeysuckle (Lonicera japonica Thunb. ) without induction of oxidative stress. Plant Physiology and Biochemistry 112:326−34

doi: 10.1016/j.plaphy.2017.01.020
[49]

Kitada C, Gong Z, Tanaka Y, Yamazaki M, Saito K. 2001. Differential expression of two cytochrome P450s involved in the biosynthesis of flavones and anthocyanins in chemo-varietal forms of Perilla frutescens. Plant and Cell Physiology 42(12):1338−44

doi: 10.1093/pcp/pce169
[50]

Zuk M, Szperlik J, Hnitecka A, Szopa J. 2019. Temporal biosynthesis of flavone constituents in flax growth stages. Plant Physiology and Biochemistry 142:234−45

doi: 10.1016/j.plaphy.2019.07.009
[51]

Kim JH, Kim BG, Park Y, Ko JH, Lim CE, et al. 2006. Characterization of flavonoid 7-O-glucosyltransferase from Arabidopsis thaliana. Bioscience, Biotechnology & Biochemistry 70(6):1471−77

doi: 10.1271/bbb.60006
[52]

Chen Z, Liu G, Tang N, Li Z. 2018. Transcriptome analysis reveals molecular signatures of luteoloside accumulation in senescing leaves of Lonicera macranthoides. International Journal of Molecular Sciences 19(4):1012

doi: 10.3390/ijms19041012
[53]

Wang T, Yang B, Guan Q, Chen X, Zhong Z, et al. 2019. Transcriptional regulation of Lonicera japonica Thunb. during flower development as revealed by comprehensive analysis of transcription factors. BMC Plant Biology 19:198

doi: 10.1186/s12870-019-1803-1
[54]

Li Y, Wang J, Li L, Song W, Li M, et al. 2023. Natural products of pentacyclic triterpenoids: from discovery to heterologous biosynthesis. Natural Product Reports 40(8):1303−53

doi: 10.1039/d2np00063f
[55]

Irmler S, Schröder G, St-Pierre B, Crouch NP, Hotze M, et al. 2000. Indole alkaloid biosynthesis in Catharanthus roseus: new enzyme activities and identification of cytochrome P450 CYP72A1 as secologanin synthase. The Plant Journal 24(6):797−804

doi: 10.1111/j.1365-313X.2000.00922.x
[56]

Collu G, Unver N, Peltenburg-Looman AM, van der Heijden R, Verpoorte R, et al. 2001. Geraniol 10-hydroxylase, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis. FEBS Letters 508(2):215−20

doi: 10.1016/s0014-5793(01)03045-9
[57]

Geu-Flores F, Sherden NH, Courdavault V, Burlat V, Glenn WS, et al. 2012. An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis. Nature 492:138−42

doi: 10.1038/nature11692
[58]

Simkin AJ, Miettinen K, Claudel P, Burlat V, Guirimand G, et al. 2013. Characterization of the plastidial geraniol synthase from Madagascar periwinkle which initiates the monoterpenoid branch of the alkaloid pathway in internal phloem associated parenchyma. Phytochemistry 85:36−43

doi: 10.1016/j.phytochem.2012.09.014
[59]

Miettinen K, Dong L, Navrot N, Schneider T, Burlat V, et al. 2014. The seco-iridoid pathway from Catharanthus roseus. Nature Communications 5:3606

doi: 10.1038/ncomms4606
[60]

Shitiz K, Sharma N, Pal T, Sood H, Chauhan RS. 2015. NGS transcriptomes and enzyme inhibitors unravel complexity of picrosides biosynthesis in Picrorhiza kurroa Royle ex. Benth. PLoS One 10(12):e0144546

doi: 10.1371/journal.pone.0144546
[61]

Jin Z, Zhu Q, Guo Y, Xing R, Wang Y, et al. 2022. Functional characterization of secologanin synthase-like homologous genes suggests their involvement in the biosynthesis of diverse metabolites in the secoiridoid biosynthetic pathway of Camptotheca acuminata Decne. International Journal of Biological Macromolecules 222:2594−602

doi: 10.1016/j.ijbiomac.2022.10.042
[62]

Zhang X, Yu Y, Jiang S, Yu H, Xiang Y, et al. 2019. Oleanane-Type Saponins Biosynthesis in Panax notoginseng via transformation of β-amyrin synthase gene from Panax japonicus. Journal of Agricultural and Food Chemistry 67(7):1982−89

doi: 10.1021/acs.jafc.8b07183
[63]

Yin X, Xiang Y, Huang FQ, Chen Y, Ding H, et al. 2023. Comparative genomics of the medicinal plants Lonicera macranthoides and L. japonica provides insight into genus genome evolution and hederagenin-based saponin biosynthesis. Plant Biotechnology Journal 21(11):2209−23

doi: 10.1111/pbi.14123
[64]

Liu Q, Khakimov B, Cárdenas PD, Cozzi F, Olsen CE, et al. 2019. The cytochrome P450 CYP72A552 is key to production of hederagenin-based saponins that mediate plant defense against herbivores. New Phytologist 222(3):1599−609

doi: 10.1111/nph.15689
[65]

Sun Q, Guo F, Ren S, Zhang L, Liu X, et al. 2023. Construction of a UDP-Arabinose Regeneration System for Efficient Arabinosylation of Pentacyclic Triterpenoids. ACS Synthetic Biology 12(8):2463−74

doi: 10.1021/acssynbio.3c00351
[66]

Cha MN, Kim HJ, Kim BG, Ahn JH. 2014. Synthesis of chlorogenic acid and p-coumaroyl shikimates from glucose using engineered Escherichia coli. Journal of Microbiology and Biotechnology 24(8):1109−17

doi: 10.4014/jmb.1403.03033
[67]

Kim BG, Jung WD, Mok H, Ahn JH. 2013. Production of hydroxycinnamoyl-shikimates and chlorogenic acid in Escherichia coli: production of hydroxycinnamic acid conjugates. Microbial Cell Factories 12:15

doi: 10.1186/1475-2859-12-15
[68]

Li S, Liang C, Liu G, Jin JM, Tao Y, et al. 2021. De novo biosynthesis of chlorogenic acid using an artificial microbial community. Journal of Agricultural and Food Chemistry 69(9):2816−25

doi: 10.1021/acs.jafc.0c07588
[69]

Zhou P, Yue C, Shen B, Du Y, Xu N, et al. 2021. Metabolic engineering of Saccharomyces cerevisiae for enhanced production of caffeic acid. Applied Microbiology and Biotechnology 105(14−15):5809−19

doi: 10.1007/s00253-021-11445-1
[70]

Niu FX, Yan ZB, Huang YB, Liu JZ. 2021. Cell-free biosynthesis of chlorogenic acid using a mixture of chassis cell extracts and purified spy-cyclized enzymes. Journal of Agricultural and Food Chemistry 69(28):7938−47

doi: 10.1021/acs.jafc.1c03309
[71]

Cho AR, Lee SJ, Kim BG, Ahn JH. 2016. Biosynthesis of three N-acetylaminosugar-conjugated flavonoids using engineered Escherichia coli. Microbial Cell Factories 15:182

doi: 10.1186/s12934-016-0582-8
[72]

Kim SY, Lee HR, Park KS, Kim BG, Ahn JH. 2015. Metabolic engineering of Escherichia coli for the biosynthesis of flavonoid-O-glucuronides and flavonoid-O-galactoside. Applied Microbiology and Biotechnology 99(5):2233−42

doi: 10.1007/s00253-014-6282-6
[73]

Liu L, Liu H, Zhang W, Yao M, Li B, et al. 2019. Engineering the biosynthesis of caffeic acid in Saccharomyces cerevisiae with heterologous enzyme combinations. Engineering 5(2):287−95

doi: 10.1016/j.eng.2018.11.029
[74]

Hill RA, Connolly JD. 2018. Triterpenoids. Natural Product Reports 35(12):1294−329

doi: 10.1039/c8np00029h
[75]

Ting HM, Wang B, Rydén AM, Woittiez L, van Herpen T, et al. 2013. The metabolite chemotype of Nicotiana benthamiana transiently expressing artemisinin biosynthetic pathway genes is a function of CYP71AV1 type and relative gene dosage. New Phytologist 199(2):352−66

doi: 10.1111/nph.12274
[76]

Hasan MM, Kim HS, Jeon JH, Kim SH, Moon, B, et al. 2014. Metabolic engineering of Nicotiana benthamiana for the increased production of taxadiene. Plant Cell Reports 33(6):895−904

doi: 10.1007/s00299-014-1568-9
[77]

Dudley QM, Jo S, Guerrero DAS, Chhetry M, Smedley MA, et al. 2022. Reconstitution of monoterpene indole alkaloid biosynthesis in genome engineered Nicotiana benthamiana. Communications Biology 5:949

doi: 10.1038/s42003-022-03904-w
[78]

Ikram NKK, Kashkooli AB, Peramuna A, Krol ARV, Bouwmeester H, et al. 2019. Insights into heterologous biosynthesis of arteannuin B and artemisinin in Physcomitrella patens. Molecules 24(21):3822

doi: 10.3390/molecules24213822
[79]

Li D, Zhang Q, Zhou Z, Zhao F, Lu W. 2016. Heterologous biosynthesis of triterpenoid dammarenediol-II in engineered Escherichia coli. Biotechnology Letters 38(4):603−9

doi: 10.1007/s10529-015-2032-9
[80]

Billingsley JM, DeNicola AB, Barber JS, Tang MC, Horecka J, et al. 2017. Engineering the biocatalytic selectivity of iridoid production in Saccharomyces cerevisiae. Metabolic Engineering 44:117−25

doi: 10.1016/j.ymben.2017.09.006
[81]

Yee DA, DeNicola AB, Billingsley JM, Creso JG, Subrahmanyam V, et al. 2019. Engineered mitochondrial production of monoterpenes in Saccharomyces cerevisiae. Metabolic Engineering 55:76−84

doi: 10.1016/j.ymben.2019.06.004
[82]

Khalid A, Takagi H, Panthee S, Muroi M, Chappell J, et al. 2017. Development of a terpenoid-production platform in Streptomyces reveromyceticus SN-593. ACS Synthetic Biology 6(12):2339−49

doi: 10.1021/acssynbio.7b00249
[83]

Duan Y, Liu J, Du Y, Pei X, Li M. 2021. Aspergillus oryzae biosynthetic platform for de novo iridoid production. Journal of Agricultural and Food Chemistry 69(8):2501−11

doi: 10.1021/acs.jafc.0c06563
[84]

Lu C, Zhang C, Zhao F, Li D, Lu W. 2018. Biosynthesis of ursolic acid and oleanolic acid in Saccharomyces cerevisiae. AIChE Journal 64(11):3794−802

doi: 10.1002/aic.16370
[85]

Li D, Wu Y, Wei P, Gao X, Li M, et al. 2020. Metabolic engineering of Yarrowia lipolytica for heterologous oleanolic acid production. Chemical eNgineering Science 218:115529

doi: 10.1016/j.ces.2020.115529
[86]

Lv Q, Xing Y, Liu J, Dong D, Liu Y, et al. 2021. Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation. Acta Pharmaceutica Sinica B 11(9):2880−99

doi: 10.1016/j.apsb.2021.03.011
[87]

Bai X, Rao X, Wang Y, Shen H, Jin X. 2023. A homogeneous Lonicera japonica polysaccharide alleviates atopic dermatitis by promoting Nrf2 activation and NLRP3 inflammasome degradation via p62. Journal of Ethnopharmacology 309:116344

doi: 10.1016/j.jep.2023.116344
[88]

Li C, Wang L, Zhao J, Wei Y, Zhai S, et al. 2022. Lonicera rupicola Hook.f.et Thoms flavonoids ameliorated dysregulated inflammatory responses, intestinal barrier, and gut microbiome in ulcerative colitis via PI3K/AKT pathway. Phytomedicine 104:154284

doi: 10.1016/j.phymed.2022.154284
[89]

Zhang B, Huang X, Niu L, Chen X, Hu B, et al. 2023. Lonicera caerulea Pomace Alleviates DSS-Induced Colitis via Intestinal Barrier Improvement and Gut Microbiota Modulation. Foods 12(18):3329

doi: 10.3390/foods12183329
[90]

Liu D, Yu X, Sun H, Zhang W, Liu G, et al. 2020. Flos Lonicerae flavonoids attenuate experimental ulcerative colitis in rats via suppression of NF-κB signaling pathway. Naunyn-Schmiedeberg's Archives of Pharmacology 393(12):2481−94

doi: 10.1007/s00210-020-01814-4
[91]

Su X, Zhu ZH, Zhang L, Wang Q, Xu MM, et al. 2021. Anti-inflammatory property and functional substances of Lonicerae japonicae Caulis. Journal of Ethnopharmacology 267:113502

doi: 10.1016/j.jep.2020.113502
[92]

Lin HW, Lee YJ, Yang DJ, Hsieh MC, Chen CC, et al. 2021. Anti-inflammatory effects of Flos Lonicerae japonicae water extract are regulated by the STAT/NF-κB pathway and HO-1 expression in virus-infected RAW264.7 cells. International Journal of Medical Sciences 18(11):2285−93

doi: 10.7150/ijms.56198
[93]

Xiong J, Li S, Wang W, Hong Y, Tang K, et al. 2013. Screening and identification of the antibacterial bioactive compounds from Lonicera japonica Thunb. leaves. Food Chemistry 138(1):327−33

doi: 10.1016/j.foodchem.2012.10.127
[94]

Li M, Wang Y, Jin J, Dou J, Guo Q, et al. 2021. Inhibitory activity of honeysuckle extracts against influenza A virus in vitro and in vivo. Virologica Sinica 36(3):490−500

doi: 10.1007/s12250-020-00302-6
[95]

Wang C, Horby PW, Hayden FG, Gao GF. 2020. A novel coronavirus outbreak of global health concern. The Lancet 395(10223):470−73

doi: 10.1016/S0140-6736(20)30185-9
[96]

Lee YR, Chang CM, Yeh YC, Huang CYF, Lin FM, et al. 2021. Honeysuckle aqueous extracts induced let-7a suppress EV71 replication and pathogenesis in vitro and in vivo and is predicted to inhibit SARS-CoV-2. Viruses 13(2):308

doi: 10.3390/v13020308
[97]

Yeh YC, Doan LH, Huang ZY, Chu LW, Shi TH, et al. 2022. Honeysuckle (Lonicera japonica) and Huangqi (Astragalus membranaceus) suppress SARS-CoV-2 entry and COVID-19 related cytokine storm in vitro. Frontiers in Pharmacology 12:765553

doi: 10.3389/fphar.2021.765553
[98]

Sosa V, Moliné T, Somoza R, Paciucci R, Kondoh H, et al. 2013. Oxidative stress and cancer: an overview. Ageing Research Reviews 12(1):376−90

doi: 10.1016/j.arr.2012.10.004
[99]

Griendling KK, Camargo LL, Rios FJ, Alves-Lopes R, Montezano AC, et al. 2021. Oxidative stress and hypertension. Circulation Research 128(7):993−1020

doi: 10.1161/CIRCRESAHA.121.318063
[100]

Liu S, Meng F, Zhang D, Shi D, Zhou J, et al. 2022. Lonicera caerulea Berry polyphenols extract alleviates exercise fatigue in mice by reducing oxidative stress, inflammation, skeletal muscle cell apoptosis, and by increasing cell proliferation. Frontiers in Nutrition 9:853225

doi: 10.3389/fnut.2022.853225
[101]

Golubev D, Zemskaya N, Shevchenko O, Shaposhnikov M, Kukuman D, et al. 2022. Honeysuckle extract (Lonicera pallasii L.) exerts antioxidant properties and extends the lifespan and healthspan of Drosophila melanogaster. Biogerontology 23(2):215−35

doi: 10.1007/s10522-022-09954-1
[102]

Xiao L, Liang S, Ge L, Wan H, Wu W, et al. 2020. 4, 5-di-O-caffeoylquinic acid methyl ester isolated from Lonicera japonica Thunb. targets the Keap1/Nrf2 pathway to attenuate H2O2-induced liver oxidative damage in HepG2 cells. Phytomedicine 70:153219

doi: 10.1016/j.phymed.2020.153219
[103]

Lin YL, Wu YHS, Chao MY, Yang DJ, Liu CW, et al. 2024. An alleviative effect of Lonicerae japonicae flos water extract against liver fibrogenesis in vitro and in vivo. Environmental Toxicology 39:2881−92

doi: 10.1002/tox.24154
[104]

Gong J, Yang F, Yang Q, Tang X, Shu F, et al. 2020. Sweroside ameliorated carbon tetrachloride (CCl4)-induced liver fibrosis through FXR-miR-29a signaling pathway. Journal of Natural Medicines 74(1):17−25

doi: 10.1007/s11418-019-01334-3
[105]

Zhou L, Wang H, Yi J, Yang B, Li M, et al. 2018. Anti-tumor properties of anthocyanins from Lonicera caerulea 'Beilei' fruit on human hepatocellular carcinoma: in vitro and in vivo study. Biomedicine & Pharmacotherapy 104:520−29

doi: 10.1016/j.biopha.2018.05.057
[106]

Guo C, Zhang X, Yu Y, Wu Y, Xie L, et al. 2022. Lonicerae japonicae flos extract and chlorogenic acid attenuates high-fat-diet- induced prediabetes via CTRPs-AdipoRs-AMPK/PPARα axes. Frontiers in Nutrition 9:1007679

doi: 10.3389/fnut.2022.1007679
[107]

Wu S, Hu R, Nakano H, Chen K, Liu M, et al. 2018. Modulation of gut microbiota by Lonicera caerulea L. Berry polyphenols in a mouse model of fatty liver induced by high fat diet. Molecules 23(12):3213

doi: 10.3390/molecules23123213
[108]

Piekarska J, Madej JP, Gorczykowski M, Szczypka M. 2023. The effects of honeysuckle (Lonicera caerulea L.) berry iridoid-anthocyanin extract on the intestinal and muscle histopathology in mice during experimental trichinellosis. Molecules 28(20):7067

doi: 10.3390/molecules28207067
[109]

Gu L, Hou Y, Wang G, Liu Q, Ding W, et al. 2022. Characterization of the chloroplast genome of Lonicera ruprechtiana Regel and comparison with other selected species of Caprifoliaceae. PLoS One 17(1):e0262813

doi: 10.1371/journal.pone.0262813
[110]

He L, Qian J, Li X, Sun Z, Xu X, et al. 2017. Complete chloroplast genome of medicinal plant Lonicera japonica: genome rearrangement, intron gain and loss, and implications for phylogenetic studies. Molecules 22(2):249

doi: 10.3390/molecules22020249
[111]

Liu ML, Fan WB, Wang N, Dong PB, Zhang TT, et al. 2018. Evolutionary analysis of plastid genomes of seven Lonicera L. species: implications for sequence divergence and phylogenetic relationships. International Journal of Molecular Sciences 19(12):4039

doi: 10.3390/ijms19124039
[112]

Daniell H, Lin CS, Yu M, Chang WJ. 2016. Chloroplast genomes: diversity, evolution, and applications in genetic engineering. Genome Biology 17:134

doi: 10.1186/s13059-016-1004-2
[113]

Ahmed I, Biggs PJ, Matthews PJ, Collins LJ, Hendy MD, et al. 2012. Mutational dynamics of aroid chloroplast genomes. Genome Biology and Evolution 4(12):1316−23

doi: 10.1093/gbe/evs110
[114]

Chen C, Qu DH, Shan FQ, Jin ZX, Sun ZS. 2022. Complete chloroplast genome of Lonicera crassifolia Batalin (Caprifoliaceae) and its phylogenetic implications. Mitochondrial DNA Part B, Resources 7(5):732−34

doi: 10.1080/23802359.2022.2068979
[115]

Srivastav M, Clement WL, Landrein S, Zhang J, Howarth DG, et al. 2023. A phylogenomic analysis of Lonicera and its bearing on the evolution of organ fusion. American Journal of Botany 110(4):e16143

doi: 10.1002/ajb2.16143
[116]

Sun QH, Morales-Briones DF, Wang HX, Landis JB, Wen J, et al. 2023. Target sequence capture data shed light on the deeper evolutionary relationships of subgenus Chamaecerasus in Lonicera (Caprifoliaceae). Molecular Phylogenetics and Evolution 184:107808

doi: 10.1016/j.ympev.2023.107808
[117]

Chen R, Gao J, Yu W, Chen X, Zhai X, et al. 2022. Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast. Nature Chemical Biology 18(5):520−29

doi: 10.1038/s41589-022-01014-6
[118]

Wang L, Li N, Yu S, Zhou J. 2023. Enhancing caffeic acid production in Escherichia coli by engineering the biosynthesis pathway and transporter. Bioresource Technology 368:128320

doi: 10.1016/j.biortech.2022.128320
[119]

Xiao F, Lian J, Tu S, Xie L, Li J, et al. 2022. Metabolic engineering of Saccharomyces cerevisiae for high-level production of chlorogenic acid from glucose. ACS Synthetic Biology 11(2):800−11

doi: 10.1021/acssynbio.1c00487
[120]

Shrestha A, Pandey RP, Dhakal D, Parajuli P, Sohng JK. 2018. Biosynthesis of flavone C-glucosides in engineered Escherichia coli. Applied Microbiology and Biotechnology 102(3):1251−67

doi: 10.1007/s00253-017-8694-6
[121]

Zhao Y, Fan J, Wang C, Feng X, Li C. 2018. Enhancing oleanolic acid production in engineered Saccharomyces cerevisiae. Bioresource Technology 257:339−43

doi: 10.1016/j.biortech.2018.02.096
[122]

Wang Y, Tan H, Wang Y, Qin JL, Zhao X, et al. 2024. High-level biosynthesis of chlorogenic acid from mixed carbon sources of xylose and glucose through a rationally refactored pathway network. Journal of Agricultural and Food Chemistry 72(7):3633−43

doi: 10.1021/acs.jafc.3c08587
[123]

Jin K, Shi X, Liu J, Yu W, Liu Y, et al. 2023. Combinatorial metabolic engineering enables the efficient production of ursolic acid and oleanolic acid in Saccharomyces cerevisiae. Bioresource Technology 374:128819

doi: 10.1016/j.biortech.2023.128819