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This is accepted manuscript by the journal but prior to copy-editing or proofing. It can be cited using the author(s), article title, journal title, year of online publication, and DOI. It will be replaced by the final typeset version, which may therefore contain changes. The DOI will be remain the same.

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Glandular trichomes: the factory of artemisinin biosynthesis

  • 1.

    Department Chinese Medicine Authentication, College of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai, 200433, China

  • 2.

    Department of Pharmacy, Shanghai Fourth People’s Hospital Affiliated to Tongji University, Shanghai, 200433, China

  • 3.

    Shanghai Key Laboratory for Pharmaceutical Metabolite Research, Shanghai, 200433, China

  • # Authors contributed equally: Qiaojuan Zhao, Mingyu Li, Minghui Zhang

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  • Plant glandular trichomes serve as a crucial secretory organ, responsible for the production, modification, and storage of a variety of vital secondary metabolites, including medicinal natural products, while also playing a role in plant defense mechanisms. Artemisia annua L. (A. annua) stands as a significant herb in Chinese traditional medicine because of its primary active compound, artemisinin, the most potent antimalarial agent. The glandular trichomes of A. annua are closely related to the synthesis and accumulation of artemisinin. As research in the field of medicinal plants progresses, the significance of glandular trichomes in the study of plant secondary metabolites has notably escalated. Given their pivotal role in artemisinin biosynthesis, the growth and development of A. annua glandular trichomes directly influence the yield and quality of artemisinin. This paper presents a comprehensive review of the latest research advancements regarding A. annua glandular trichomes, encompassing their morphology, function, growth, and developmental influencing factors, and the artemisinin biosynthesis pathway. The aim is to provide substantial support for ongoing investigations into the growth and development of A. annua glandular trichomes and the underlying mechanisms of metabolic regulation.

  • Cite this article

    Zhao Q, Li M, Zhang M, Tan H. 2024. Glandular trichomes: the factory of artemisinin biosynthesis. Medicinal Plant Biology doi: 10.48130/mpb-0024-0018
    Zhao Q, Li M, Zhang M, Tan H. 2024. Glandular trichomes: the factory of artemisinin biosynthesis. Medicinal Plant Biology doi: 10.48130/mpb-0024-0018
    shu

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Biosynthesis and Regulation of Traditional Medicinal Compounds

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Important Notice

This is accepted manuscript by the journal but prior to copy-editing or proofing. It can be cited using the author(s), article title, journal title, year of online publication, and DOI. It will be replaced by the final typeset version, which may therefore contain changes. The DOI will be remain the same.

REVIEW   Open Access    

Glandular trichomes: the factory of artemisinin biosynthesis

  • 1.

    Department Chinese Medicine Authentication, College of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai, 200433, China

  • 2.

    Department of Pharmacy, Shanghai Fourth People’s Hospital Affiliated to Tongji University, Shanghai, 200433, China

  • 3.

    Shanghai Key Laboratory for Pharmaceutical Metabolite Research, Shanghai, 200433, China

  • Received: 12 June 2024
  • Accepted: 22 July 2024
    • First-online: 26 July 2024
Medicinal Plant Biology  Article in press  (2024)  |  Cite this article

Abstract: Plant glandular trichomes serve as a crucial secretory organ, responsible for the production, modification, and storage of a variety of vital secondary metabolites, including medicinal natural products, while also playing a role in plant defense mechanisms. Artemisia annua L. (A. annua) stands as a significant herb in Chinese traditional medicine because of its primary active compound, artemisinin, the most potent antimalarial agent. The glandular trichomes of A. annua are closely related to the synthesis and accumulation of artemisinin. As research in the field of medicinal plants progresses, the significance of glandular trichomes in the study of plant secondary metabolites has notably escalated. Given their pivotal role in artemisinin biosynthesis, the growth and development of A. annua glandular trichomes directly influence the yield and quality of artemisinin. This paper presents a comprehensive review of the latest research advancements regarding A. annua glandular trichomes, encompassing their morphology, function, growth, and developmental influencing factors, and the artemisinin biosynthesis pathway. The aim is to provide substantial support for ongoing investigations into the growth and development of A. annua glandular trichomes and the underlying mechanisms of metabolic regulation.

    Acknowledgments

    • This work was supported by grants from the National Natural Science Foundation of China (82122072), the Natural Science Foundation of Shanghai Municipality (21ZR1477800), and the Traditional Chinese Medicine Research Project of Shanghai (2024PT010). The authors declare that they have no competing interests.

    Conflict of interest

    • The authors declare that they have no conflict of interest. Hexin Tan is the Editorial Board member of Medicinal Plant Biology. She was blinded from reviewing or making decisions on the manuscript. The article was subject to the journal's standard procedures, with peer-review handled independently of Dr. Tan and her research group.

    • # Authors contributed equally: Qiaojuan Zhao, Mingyu Li, Minghui Zhang

    Rights and permissions
    • Copyright: © 2024 by the author(s). Published by Maximum Academic Press, Fayetteville, GA. This article is an open access article distributed under Creative Commons Attribution License (CC BY 4.0), visit https://creativecommons.org/licenses/by/4.0/.
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    Cite this article
    Zhao Q, Li M, Zhang M, Tan H. 2024. Glandular trichomes: the factory of artemisinin biosynthesis. Medicinal Plant Biology doi: 10.48130/mpb-0024-0018
    Zhao Q, Li M, Zhang M, Tan H. 2024. Glandular trichomes: the factory of artemisinin biosynthesis. Medicinal Plant Biology doi: 10.48130/mpb-0024-0018
    shu

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