Systemic review of <i>Macleaya cordata</i>: genetics, biosynthesis of active ingredient and functions

Peng Huang; Pi Cheng; Mengshan Sun; Xiubin Liu; Zhixing Qing; YiSong Liu; Zihui Yang; Hua Liu; Changhong Li; Jianguo Zeng; Peng Huang; Pi Cheng; Mengshan Sun; Xiubin Liu; Zhixing Qing; YiSong Liu; Zihui Yang; Hua Liu; Changhong Li; Jianguo Zeng

doi:10.48130/mpb-0024-0019

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Systemic review of Macleaya cordata: genetics, biosynthesis of active ingredient and functions

1.
Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan Agricultural University, Changsha 410128, Hunan, China
2.
Traditional Chinese Medicine Breeding Center of Yuelushan Laboratory, Changsha 410128, Hunan, China
3.
College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, Hunan, China
4.
Hunan Institute of Agricultural Environment and Ecology, Hunan Academy of Agricultural Sciences, Changsha 410125, Hunan, China
5.
Micolta Bioresource Inc., Changsha 410016, Hunan, China
6.
National and Local Union Engineering Research Center of Veterinary Herbal Medicine Resource and Initiative, Hunan Agricultural University, Changsha 410128, Hunan, China

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Corresponding author: zengjianguo@hunau.edu.cn

Received: 20 May 2024
Revised: 19 July 2024
Accepted: 26 July 2024
First-online: 07 August 2024
Medicinal Plant Biology Article in press | Cite this article

Abstract

Macleaya cordata, a medicinal plant in the Papaveraceae family, is rich in bioactive benzylisoquinoline alkaloids. Recent research has elucidated the mechanisms by which these active components promote livestock and poultry growth and exhibit anti-inflammatory effects on the intestines. These findings have led to the development of two raw medicinal materials and two veterinary drug formulations, widely used in China's livestock industry. Advances in multi-omics technologies, such as whole-genome sequencing and transcriptomics, have clarified the chemical composition of alkaloids and the biosynthesis of sanguinarine, enabling its de novo synthesis in yeast. Efforts in plant breeding have focused on cultivar selection and germplasm innovation, establishing DUS (Distinctness, Uniformity, and Stability) testing guidelines. Genetic engineering techniques have re-edited the sanguinarine pathway and induced hairy roots and cell suspension cultures in M. cordata. These advancements reduce production costs, ensure product stability, and promote sustainable production. This paper reviews the species origin, current research status, and future prospects of M. cordata, offering guidance for further research on this valuable resource.
- Review,
- Macleaya cordata,
- Systemic,
- Genetics,
- Biosysnthesis,
- Active
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Copyright: © 2024 by the author(s). Published by Maximum Academic Press, Fayetteville, GA. This article is an open access article distributed under Creative Commons Attribution License (CC BY 4.0), visit https://creativecommons.org/licenses/by/4.0/.

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Huang P, Cheng P, Sun M, Liu X, Qing Z, et al. 2024. Systemic review of Macleaya cordata: genetics, biosynthesis of active ingredient and functions. Medicinal Plant Biology doi: 10.48130/mpb-0024-0019

Huang P, Cheng P, Sun M, Liu X, Qing Z, et al. 2024. Systemic review of Macleaya cordata: genetics, biosynthesis of active ingredient and functions. Medicinal Plant Biology doi: 10.48130/mpb-0024-0019

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Systemic review of Macleaya cordata: genetics, biosynthesis of active ingredient and functions

1.
Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan Agricultural University, Changsha 410128, Hunan, China
2.
Traditional Chinese Medicine Breeding Center of Yuelushan Laboratory, Changsha 410128, Hunan, China
3.
College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, Hunan, China
4.
Hunan Institute of Agricultural Environment and Ecology, Hunan Academy of Agricultural Sciences, Changsha 410125, Hunan, China
5.
Micolta Bioresource Inc., Changsha 410016, Hunan, China
6.
National and Local Union Engineering Research Center of Veterinary Herbal Medicine Resource and Initiative, Hunan Agricultural University, Changsha 410128, Hunan, China

Corresponding author: zengjianguo@hunau.edu.cn

Received: 20 May 2024
Revised: 19 July 2024
Accepted: 26 July 2024

First-online: 07 August 2024

Medicinal Plant Biology Article in press () | Cite this article

Abstract: Macleaya cordata, a medicinal plant in the Papaveraceae family, is rich in bioactive benzylisoquinoline alkaloids. Recent research has elucidated the mechanisms by which these active components promote livestock and poultry growth and exhibit anti-inflammatory effects on the intestines. These findings have led to the development of two raw medicinal materials and two veterinary drug formulations, widely used in China's livestock industry. Advances in multi-omics technologies, such as whole-genome sequencing and transcriptomics, have clarified the chemical composition of alkaloids and the biosynthesis of sanguinarine, enabling its de novo synthesis in yeast. Efforts in plant breeding have focused on cultivar selection and germplasm innovation, establishing DUS (Distinctness, Uniformity, and Stability) testing guidelines. Genetic engineering techniques have re-edited the sanguinarine pathway and induced hairy roots and cell suspension cultures in M. cordata. These advancements reduce production costs, ensure product stability, and promote sustainable production. This paper reviews the species origin, current research status, and future prospects of M. cordata, offering guidance for further research on this valuable resource.

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Acknowledgments

This work was supported by Hunan Provincial Natural Science Foundation of China (2023JJ40367 & 2023JJ30341).

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The authors declare that they have no conflict of interest.

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Copyright: © 2024 by the author(s). Published by Maximum Academic Press, Fayetteville, GA. This article is an open access article distributed under Creative Commons Attribution License (CC BY 4.0), visit https://creativecommons.org/licenses/by/4.0/.

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